Alcohol Drinking Pattern and Risk of Head and Neck Cancer

A Nationwide Cohort Study

Bibliographic Data

ID15499145
AuthorsHye Yeon Koo (0000-0002-0387-4278, CHA University Bundang Medical Center), Kyungdo Han (0000-0002-6096-1263, Soongsil University), Dong Wook Shin (0000-0001-8128-8920, Samsung Medical Center, corresponding author), Jung Eun Yoo (0000-0001-8344-6291, Seoul National University Hospital), Mi Hee Cho (0000-0002-3705-0285, Kangbuk Samsung Hospital), Keun Hye Jeon (0000-0003-2294-0637, CHA University), Dahye Kim (0000-0002-5238-7361, Catholic University of Korea), Sang-Duk Hong (Samsung Medical Center), Sangduk Hong (Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea), Jae Kwan Jun (0000-0003-1647-0675, National Cancer Center)
Year2021
Volume18
Issue21
Pages11204-11204
Publication date2021-10-25
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182111204
PMID34769724
OpenAlexW3208350278
LanguageEN
Citations received1
References cited51

Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency ( p -trend p -trend 14 units/occasion (aHR 1.26, 95% CI 1.13-1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption

Alcohol · Alcohol consumption · Biology · Cancer · Cohort · Cohort study · Confidence interval · Environmental health · Hazard ratio · Head and neck cancer · Larynx · Pharynx · Population · Proportional hazards model · Risk factor · Alcohol Consumption and Health Effects · Demography · Hops Chemistry and Applications · Medicine · Peroxisome Proliferator-Activated Receptors · Internal Medicine · Surgery

Tools

Open DOIOpen Access