Development of Nonlaboratory-Based Risk Prediction Models for Cardiovascular Diseases Using Conventional and Machine Learning Approaches

Bibliographic Data

ID15499842
AuthorsMirza Rizwan Sajid (0000-0002-0358-2195, University of Gujrat, corresponding author), Bader A Almehmadi (0000-0002-5609-9914, Majmaah University), Waqas Sami (0000-0001-7948-1190, Majmaah University), Mansour K Alzahrani (Majmaah University), Noryanti Muhammad (0000-0002-6112-3720, Universiti Malaysia Pahang Al-Sultan Abdullah), Christophe Chesneau (0000-0002-1522-9292, Université de Caen Normandie), Asif Hanif (0000-0002-2670-6402, University of Lahore), Arshad Ali Khan (0000-0002-4229-564X, Universiti Malaysia Pahang Al-Sultan Abdullah), Ahmad Shahbaz (0000-0001-5695-8208, Punjab Institute of Cardiology)
Year2021
Volume18
Issue23
Pages12586-12586
Publication date2021-11-29
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182312586
PMID34886312
OpenAlexW3216327913
LanguageEN
References cited40

Criticism of the implementation of existing risk prediction models (RPMs) for cardiovascular diseases (CVDs) in new populations motivates researchers to develop regional models. The predominant usage of laboratory features in these RPMs is also causing reproducibility issues in low-middle-income countries (LMICs). Further, conventional logistic regression analysis (LRA) does not consider non-linear associations and interaction terms in developing these RPMs, which might oversimplify the phenomenon. This study aims to develop alternative machine learning (ML)-based RPMs that may perform better at predicting CVD status using nonlaboratory features in comparison to conventional RPMs. The data was based on a case-control study conducted at the Punjab Institute of Cardiology, Pakistan. Data from 460 subjects, aged between 30 and 76 years, with (1:1) gender-based matching, was collected. We tested various ML models to identify the best model/models considering LRA as a baseline RPM. An artificial neural network and a linear support vector machine outperformed the conventional RPM in the majority of performance matrices. The predictive accuracies of the best performed ML-based RPMs were between 80.86 and 81.09% and were found to be higher than 79.56% for the baseline RPM. The discriminating capabilities of the ML-based RPMs were also comparable to baseline RPMs. Further, ML-based RPMs identified substantially different orders of features as compared to baseline RPM. This study concludes that nonlaboratory feature-based RPMs can be a good choice for early risk assessment of CVDs in LMICs. ML-based RPMs can identify better order of features as compared to the conventional approach, which subsequently provided models with improved prognostic capabilities

Baseline (sea · Biology · Logistic regression · Machine learning · Matching (statistics · Pathology · Predictive modelling · Support vector machine · Artificial Intelligence in Healthcare · Blood Pressure and Hypertension Studies · Computer Science · Global Public Health Policies and Epidemiology · Medicine · Artificial Intelligence

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