A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

Bibliographic Data

ID15501043
AuthorsFarzaneh Allahdinian Hesaruiyeh (Islamic Azad University of Shahreza), Saeed Rajabi (0000-0002-0082-104X, Shiraz University of Medical Sciences), Mohadeseh Motamed‐Jahromi (0000-0001-6025-4879, Fasa University of Medical Sciences), Mohammad Sarhadi (0000-0002-3766-7664, Zahedan University of Medical Sciences), Mary Lou Bell (0000-0002-3965-1359, Yale University), Razieh Khaksefidi (0000-0002-0117-5967, Shiraz University of Medical Sciences), Somayeh Sarhadi (0000-0002-9657-4791, Islamic Azad University of Hamedan), Leili Mohammadi (Zahedan University of Medical Sciences), Kamal Dua (0000-0002-7507-1159, University of Technology Sydney), Amin Mohammadpour (0000-0001-9485-0636, Shiraz University of Medical Sciences, corresponding author), Paolo Martelletti (0000-0002-6556-4128, Sapienza University of Rome, corresponding author)
Year2022
Volume19
Issue15
Pages9110-9110
Publication date2022-07-26
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19159110
PMID35897481
OpenAlexW4288041893
LanguageEN
References cited2

While a large body of literature has shown the health problems of illicit drug use, research is needed on how substance abuse impacts DNA damage and contaminants in blood, especially given Pb-contaminated opium. This pilot study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addict people. The current study is a case-control study with a cross-sectional design. A sample of 50 opium-addicted and non-addict adults were chosen for this study using convenience and random sampling methods. Participants were divided into two groups: addicts and non-addicts. The atomic absorption spectroscopy method was used to measure the quantity of Pb, and the Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure the amount of 8-oxo-Gua and MDA. The data were analyzed using an independent t-test. The results show that the amount of Pb in the blood serum of addicted women and men was higher than levels in non-addict men and women, for the study participants ( p -value = 0.001). Blood levels were not significantly different between addicts and non-addicts for men or women for 8-oxo-Gua ( p -value = 0.647 for women and p -value = 0.785 for men) and MDA ( p -value = 0.867 for women and p -value = 0.995 for men). In general, addicts' blood Pb levels were found to be substantially higher than those of normal non-addict persons in this pilot study. As a result, testing for blood Pb levels in addicts may be informative in instances when symptoms are inconclusive

Addiction · Cross-sectional study · Drug addict · Malondialdehyde · Opium · Oxidative stress · Pathology · Psychiatry · Heavy Metal Exposure and Toxicity · Medicine · Pharmacological Effects and Toxicity Studies · Internal Medicine