The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients
Bibliographic Data
| ID | 15501749 |
|---|---|
| Authors | Kiduk Kim (0000-0003-2256-1821, Eulji University), Kyoonho Kang (Eulji University), Hyewon Sheol (Eulji University), Jihae Shin (0000-0001-6034-2027, Eulji University), Youngseo Sim (Eulji University), Tae-Hoon Yang (Eulji University), Jeong-Won Hwang (Eulji University), Jumi Lee (0000-0003-0343-4616, Eulji University, corresponding author) |
| Year | 2022 |
| Volume | 19 |
| Issue | 3 |
| Pages | 1042-1042 |
| Publication date | 2022-01-18 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19031042 |
| PMID | 35162067 |
| OpenAlex | W4206334864 |
| Language | EN |
| References cited | 5 |
Non-alcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) levels are risk factors for developing cardiovascular disease (CVD). Additionally, previous studies have suggested that high SUA levels increase the risk of having NAFLD. However, no study has investigated the relationship between SUA and CVD risk in NAFLD. This study analyzed the relationship between SUA and CVD in NAFLD. Data for this study used the 2016-2018 Korean National Health and Nutrition Examination Survey, which represents the Korean population. A total of 11,160 NAFLD patients were included. Participants with hepatic steatosis index ≥ 30 were considered to have NAFLD. Ten-year CVD risk was estimated using an integer-based Framingham risk score. Estimated 10-year CVD risk ≥ 20% was considered high risk. Multiple logistic regression was conducted to calculate the odds ratios (ORs) associated with SUA level and CVD risk. High CVD risk OR increases by 1.31 (95% CI 1.26-1.37) times per 1 mg/dL of SUA. After adjustment, SUA still had an increased risk (OR 1.44; 95% CI 1.38-1.51) of CVD. Compared with the lowest SUA quartile group, the highest quartile group showed a significantly higher risk of having CVD before (OR 2.76; 95% CI 2.34-3.25) and after (OR 4.01; 95% CI 3.37-4.78) adjustment. SUA is independently associated with CVS risk in NAFLD
Confidence interval · Disease · Environmental health · Fatty liver · Framingham Risk Score · Metabolic syndrome · National Health and Nutrition Examination Survey · Obesity · Odds ratio · Population · Quartile · Risk factor · Uric acid · Alcohol Consumption and Health Effects · Gout, Hyperuricemia, Uric Acid · Liver Disease Diagnosis and Treatment · Medicine · Gastroenterology · Internal Medicine
| Highly cited | No |
|---|