Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia

An Italian Case–Control Study

Bibliographic Data

ID15502633
AuthorsRiccardo Mazzoli (0009-0003-2659-8434, University of Modena and Reggio Emilia), Annalisa Chiari (0000-0003-3052-2865, Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy), Marco Vitolo (0000-0002-5196-6249, University of Modena and Reggio Emilia), Caterina Garuti (0000-0001-6242-531X, University of Modena and Reggio Emilia), Giorgia Adani (University of Modena and Reggio Emilia), Giulia Vinceti (0000-0003-1055-8908, Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy), Giovanna Zamboni (0000-0002-6133-3373, University of Modena and Reggio Emilia), Manuela Tondelli (0000-0001-6698-5437, University of Modena and Reggio Emilia), C Galli (0000-0001-9393-888X, Azienda Unita' Sanitaria Locale Di Modena), Manuela Costa (0000-0001-5564-555X, Azienda Unita' Sanitaria Locale Di Modena), Simone Salemme (0000-0002-9260-9993, Università di Camerino), Giuseppe Boriani (0000-0002-9820-4815, University of Modena and Reggio Emilia), Marco Vinceti (0000-0002-0551-2473, Boston University, corresponding author), Tommaso Filippini (0000-0003-2100-0344, University of Modena and Reggio Emilia)
Year2024
Volume21
Issue6
Pages688-688
Publication date2024-05-27
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph21060688
PMID38928935
OpenAlexW4399091895
LanguageEN
References cited64

Dementia is a major neurologic syndrome characterized by severe cognitive decline, and it has a detrimental impact on overall physical health, leading to conditions such as frailty, changes in gait, and fall risk. Depending on whether symptoms occur before or after the age of 65, it can be classified as early-onset (EOD) or late-onset (LOD) dementia. The present study is aimed at investigating the role of cardiovascular factors on EOD and LOD risk in an Italian population. Using a case-control study design, EOD and LOD cases were recruited at the Modena Cognitive Neurology Centers in 2016-2019. Controls were recruited among caregivers of all the dementia cases. Information about their demographics, lifestyles, and medical history were collected through a tailored questionnaire. We used the odds ratio (OR) and 95% confidence interval (CI) to estimate the EOD and LOD risk associated with the investigated factors after adjusting for potential confounders. Of the final 146 participants, 58 were diagnosed with EOD, 34 with LOD, and 54 were controls. According to their medical history, atrial fibrillation was associated with increased disease risk (ORs 1.90; 95% CI 0.32-11.28, and 3.64; 95% CI 0.32-41.39 for EOD and LOD, respectively). Dyslipidemia and diabetes showed a positive association with EOD, while the association was negative for LOD. We could not evaluate the association between myocardial infarction and EOD, while increased risk was observed for LOD. No clear association emerged for carotid artery stenosis or valvular heart disease. In this study, despite the limited number of exposed subjects and the high imprecision of the estimates, we found positive associations between cardiovascular disease, particularly dyslipidemia, diabetes, and atrial fibrillation, and EOD

Atrial fibrillation · Confidence interval · Coronary artery disease · Dementia · Diabetes mellitus · Disease · Dyslipidemia · Environmental health · Myocardial infarction · Odds ratio · Physical therapy · Population · Alzheimer's disease research and treatments · Cerebrovascular and genetic disorders · Dementia and Cognitive Impairment Research · Medicine · Internal Medicine

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