Classification of primary progressive aphasia and its variants

Dados Bibliográficos

ID23320428
AutoresM L Gorno-Tempini (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Maria‐Luisa Gorno‐Tempini (Johns Hopkins University), Argye E Hillis (0000-0002-5192-1171, Johns Hopkins University), Sandra Weıntraub (0000-0003-2605-5205, Johns Hopkins University), S Weintraub (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Andrew Kertesz (0000-0002-8658-7046, Johns Hopkins University), Mario F Mendez (0000-0001-6441-7989, Johns Hopkins University), M Mendez (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Stefano F Cappa (0000-0003-1003-3925, Johns Hopkins University), J M Ogar (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), J Ogar (Johns Hopkins University), Jonathan D Rohrer (0000-0002-6155-8417, Johns Hopkins University), Sandra E Black (0000-0001-7093-8289, Johns Hopkins University), S Black (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Bradley F Boeve (0000-0002-4153-8187, Mayo Clinic), Facundo Manes (0000-0002-1899-1426, Johns Hopkins University), Nina F Dronkers (0000-0003-4462-2963, Johns Hopkins University), Rik Vandenberghe (0000-0001-6237-2502, Johns Hopkins University), Katya Rascovsky (Johns Hopkins University), Karalyn Patterson (0000-0003-1927-7424, Johns Hopkins University), Bruce L Miller (0000-0002-2152-4220, Johns Hopkins University), David S Knopman (0000-0002-6544-066X, Mayo Clinic), J R Hodges (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), M M Mesulam (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Marsel Mesulam (0000-0001-5731-851X, Johns Hopkins University), M Grossman (From the Memory and Aging Centre (M.L.G.-T., J.M.O., K.R., B.L.M.), Department of Neurology, University of California at San Francisco, San Francisco; Center for Mind/Brain Sciences (M.L.G.-T.), University of Trento, Trento, Italy; Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD; Department of Neurology (S.W., M.M.M.), Northwestern University, Chicago, IL; Cognitive Neurology (A.K.), University of Western Ontario, London, Canada; Department of Neurology (M.M.), University...), Owen A Ross (0000-0003-4813-756X, Johns Hopkins University)
Ano2011
Volume76
Fascículo11
Páginas1006-1014
Data de publicação2011-03-15
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoNeurology (JOURNAL)
Identificadores do periódicoISSN: 0028-3878 • E-ISSN: 1526-632X
EditoraOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1212/wnl.0b013e31821103e6
PMID21325651
PMCIDPMC3059138
OpenAlexW2138190873
IdiomaEN
Citações recebidas60
Referências citadas48

This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for the 3 variants of PPA--nonfluent/agrammatic, semantic, and logopenic--were developed by an international group of PPA investigators who convened on 3 occasions to operationalize earlier published clinical descriptions for PPA subtypes. Patients are first diagnosed with PPA and are then divided into clinical variants based on specific speech and language features characteristic of each subtype. Classification can then be further specified as "imaging-supported" if the expected pattern of atrophy is found and "with definite pathology" if pathologic or genetic data are available. The working recommendations are presented in lists of features, and suggested assessment tasks are also provided. These recommendations have been widely agreed upon by a large group of experts and should be used to ensure consistency of PPA classification in future studies. Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations.

Aphasia · Cognitive psychology · Consistency (knowledge bases) · Dementia · Disease · Frontotemporal dementia · Natural language processing · Operationalization · Pathology · Primary progressive aphasia · Reliability (semiconductor) · Artificial Intelligence · Computer Science · Genomics and Rare Diseases · Medicine · Neurobiology of Language and Bilingualism · Psychology · S100 Proteins and Annexins