Workplace Culture and Biomarkers of Health Risk

Bibliographic Data

ID15512230
AuthorsBrad Shuck (0000-0001-8768-7690, University of Louisville), Joy L Hart (0000-0003-3220-2638, University of Louisville), Kandi L Walker (0000-0003-1719-588X, University of Louisville), Jayesh Rai (University of Louisville), Shweta Srivastava (0000-0003-3922-0070, University of Louisville), Sanjay Srivastava (0000-0002-0426-1692, University of Louisville), N Shesh (0000-0002-8377-353X, University of Louisville), Aruni Bhatnagar (0000-0002-6906-6345, University of Louisville), Rachel J Keith (0000-0003-3877-0636, University of Louisville, corresponding author)
Year2022
Volume19
Issue19
Pages11920-11920
Publication date2022-09-21
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph191911920
PMID36231223
OpenAlexW4296626630
LanguageEN
References cited8

Workplace culture has been studied for impact on health risk; however, connections with robust biologic markers of health remain to be established. We examined associations between the work environment and urinary levels of catecholamines and their metabolites as biomarkers of sympathetic nervous system activity, indicative of stress. We recruited participants (n = 219; 2018-2019) from a cardiovascular risk cohort to investigate workplace culture, well-being, and stress. Participants completed seven questionnaires. Urine samples were used to measure catecholamines and their metabolites by LC/MS/MS. Pearson correlation and linear regression models were used after adjusting for demographics and creatinine. Participants reporting higher well-being had lower urinary levels of dopamine, serotonin, and 3-methoxytyramine. Participants reporting a more engaged and more positive workplace had lower levels of dopamine and 3-methoxytyramine. Reported workplace isolation was correlated with higher levels of dopamine and 3-methoxytyramine. Given correlations between catecholamines, we used 3-methoxytyramine for linear regression. In fully adjusted models, in environments with a more positive culture, levels of 3-methoxytyramine remained lower (β = -0.065 ± 0.025, p = 0.01) and indicated a positive association between workplace isolation and 3-methoxytyramine (β = 0.064 ± 0.030, p = 0.04). These findings are consistent with an important relationship between workplace environment and sympathetic nervous system activity

Cohort · Cohort study · Creatinine · Urinary system · Urine · Heart Rate Variability and Autonomic Control · Medicine · Mental Health Research Topics · Psychology · Stress Responses and Cortisol · Internal Medicine · Physiology

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