Monoclonal Antibodies against Sars-CoV-2
Potential Game-Changer Still Underused
Bibliographic Data
| ID | 15512549 |
|---|---|
| Authors | Ivan Gentile (0000-0002-5199-8451, University of Naples Federico II, corresponding author), Alberto Enrico Maraolo (0000-0002-7218-7762, Ospedale D. Cotugno), Antonio Riccardo Buonomo (0000-0002-4378-8366, University of Naples Federico II), Mariano Nobile (0000-0003-0324-0125, University of Naples Federico II), Prisco Piscitelli (0000-0003-4556-6182, University of Naples Federico II), Alessandro Miani (0000-0001-6610-3510, University of Milan), Nicola Schiano Moriello (0000-0001-8474-4776, University of Naples Federico II) |
| Year | 2021 |
| Volume | 18 |
| Issue | 21 |
| Pages | 11159-11159 |
| Publication date | 2021-10-24 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph182111159 |
| PMID | 34769678 |
| OpenAlex | W3210355646 |
| Language | EN |
| References cited | 9 |
Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to severe disease. Based on data of the Italian Ministry of Health, in the period April-August 2021, monoclonal antibodies were prescribed to 6322 patients. In the same period, 70,022 patients over 70 years old became infected with SARS-CoV-2. Even considering that all monoclonal antibodies were prescribed to this category of patients, we calculated that only 9% of these subjects received the treatment. Moreover, using efficacy data provided by clinal trials, we estimated the potential benefit in terms of reduction of hospital admissions and deaths. Considering utilisation of monoclonal antibodies in half infected patients over 70 years, we estimated that hospital admissions and deaths might have been reduced by 7666 and 3507, respectively. Finally, we calculated the economic benefit of monoclonal use. In the same scenario (50% use of monoclonal antibodies to patients over 70), we estimated potential savings of USD 117,410,105. In conclusion, monoclonal antibodies were used in a small proportion of patients over 70 in Italy. A more extensive use might have resulted in a marked decrease in hospital admissions, deaths and in conspicuous saving for the health system
2019-20 coronavirus outbreak · Antibody · Christian ministry · Coronavirus disease 2019 (COVID-19 · Disease · Infectious disease (medical specialty · Monoclonal antibody · Outbreak · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 · Vaccination · COVID-19 Clinical Research Studies · COVID-19 epidemiological studies · Medicine · SARS-CoV-2 and COVID-19 Research · Emergency Medicine · Immunology · Internal Medicine · Virology
| Citation velocity | historical |
|---|---|
| Highly cited | No |