Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients

Bibliographic Data

ID15515906
AuthorsKatarzyna Orlewska (0000-0001-7123-1066, Jan Kochanowski University, corresponding author), Justyna Klusek (0000-0002-1098-8919, Jan Kochanowski University), Stanisław Głuszek (0000-0001-7752-0459, Jan Kochanowski University), Jolanta Klusek (Jan Kochanowski University), Bartosz Witczak (Jan Kochanowski University), Monika Wawszczak-Kasza (0000-0002-9153-2250, Jan Kochanowski University), Monika Wawszczak (Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland), Łukasz Madej (0000-0003-1032-6963, Jan Kochanowski University), Michał Marzec (0000-0001-9698-6019, University of Copenhagen), Ewa Orlewska (0000-0001-5731-4316, Jan Kochanowski University)
Year2023
Volume20
Issue2
Pages1520-1520
Publication date2023-01-13
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph20021520
PMID36674274
OpenAlexW4316371682
LanguageEN
References cited35

GST (glutathione S-transferases) are capable of influencing glucose homeostasis, probably through regulation of the response to oxidant stress. The aim of our study was to investigate the relationship between GSTP1 gene polymorphism and glycated hemoglobin (HbA1c) levels in type two diabetic (T2D) patients. A total of 307 T2D patients were included. Analysis of the GSTP1 gene polymorphism (rs1695) was conducted using the TaqMan qPCR method endpoint genotyping. HbA1c was determined using a COBAS 6000 autoanalyzer. A univariable linear regression and multivariable linear regression model were used to investigate the association between mean HbA1c level and GSTP1 gene polymorphism, age at T2D diagnosis, T2D duration, therapy with insulin, gender, BMI, smoking status. GSTP1 Val/Val genotype, age at T2D diagnosis, T2D duration and therapy with insulin were statistically significant contributors to HbA1c levels (p < 0.05). Multivariable regression analysis revealed that GSTP1 (Val/Val vs. Ile/Ile) was associated with higher HbA1c even after adjustment for variables that showed a statistically significant relationship with HbA1c in univariable analyses (p = 0.024). The results suggest that GSTP polymorphism may be one of the risk factors for higher HbA1c in T2D patients. Our study is limited by the relatively small sample size, cross-sectional design, and lack of inclusion of other oxidative stress-related genetic variants

Biology · Diabetes mellitus · Enzyme · Glutathione · Glutathione S-transferase · Glutathione transferase · Transferase · Type (biology · Type 1 diabetes · Type 2 diabetes · Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Liver Disease Diagnosis and Treatment · Medicine · Biochemistry · Ecology · Endocrinology · Genetics · Internal Medicine

Tools

Open DOIOpen Access