White Matter Correlates of Theory of Mind in Patients With First-Episode Psychosis
Bibliographic Data
| ID | 15516353 |
|---|---|
| Authors | Nahrie Suk Kim (Seoul National University), Tae Young Lee (0000-0002-0238-8147, Pusan National University Yangsan Hospital), Wu Jeong Hwang (0000-0002-2546-3103, Seoul National University), Yoo Bin Kwak (0000-0001-6959-495X, Seoul National University), Seowoo Kim (0000-0003-4277-7152, Seoul National University), Sun-Young Moon (Seoul National University), Silvia Kyungjin Lho (0000-0001-7164-9358, Seoul National University), Sanghoon Oh (0000-0002-7394-5211, Seoul National University), Jun Soo Kwon (0000-0002-1060-1462, Seoul National University, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 617683-617683 |
| Publication date | 2021-03-05 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.617683 |
| PMID | 33746794 |
| OpenAlex | W3134239994 |
| Language | EN |
| References cited | 93 |
Deficits in theory of mind (ToM) are considered as a distinctive feature of schizophrenia. Functional magnetic resonance imaging (fMRI) studies have suggested that aberrant activity among the regions comprising the mentalizing network is related to observed ToM deficits. However, the white matter structures underlying the ToM functional network in schizophrenia remain unclear. To investigate the relationship between white matter integrity and ToM impairment, 35 patients with first-episode psychosis (FEP) and 29 matched healthy controls (HCs) underwent diffusion tensor imaging (DTI). Using tract-based spatial statistics (TBSS), fractional anisotropy (FA) values of the two regions of interest (ROI)-the cingulum and superior longitudinal fasciculus (SLF)-were acquired, and correlational analysis with ToM task scores was performed. Among the patients with FEP, ToM strange story scores were positively correlated with the FA values of the left cingulum and left SLF. There was no significant correlation between FA and ToM task scores in HCs. These results suggest that the left cingulum and SLF constitute a possible neural basis for ToM deficits in schizophrenia. Our study is the first to demonstrate the white matter connectivity underlying the mentalizing network, as well as its relation to ToM ability in patients with FEP
Cingulum (brain · Cognition · Cognitive psychology · Diffusion MRI · Fasciculus · Fractional anisotropy · Functional connectivity · Functional magnetic resonance imaging · Magnetic resonance imaging · Mentalization · Psychiatry · Psychosis · Radiology · Schizophrenia (object-oriented programming · Theory of mind · Uncinate fasciculus · White matter · Advanced Neuroimaging Techniques and Applications · Fetal and Pediatric Neurological Disorders · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment
An advanced test of theory of mind
The Neural Basis of Mentalizing
“John thinks that Mary thinks that…” attribution of second-order beliefs by 5- to 10-year-old children
The Neural Bases of Social Cognition and Story Comprehension
Tract-based spatial statistics
The relationship between neurocognition and social cognition with functional outcomes in schizophrenia
Fractionating theory of mind
The social brain in adolescence
Social cognition in schizophrenia
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
| Highly cited | No |
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