Serum Testosterone Levels and Symptom-Based Depression Subtypes in Men
Bibliographic Data
| ID | 15517072 |
|---|---|
| Authors | Stephanie Rodgers (0000-0003-2811-7991, University of Zurich), Martin Grosse Holtforth (0000-0003-0674-8741, Bern University of Applied Sciences), Michael P Hengartner (0000-0002-2956-2969, ZHAW Zurich University of Applied Sciences), Mario Müller (0000-0001-7071-3717, University of Zurich), Aleksandra Aleksandrowicz (University Hospital of Zurich), Aleksandra A Aleksandrowicz, Wulf Rössler (0000-0003-0049-4533, University of Zurich), Vladeta Ajdacic-Gro (0000-0002-7032-9237, University Hospital of Zurich, corresponding author), Vladeta Ajdacic-Gross |
| Year | 2015 |
| Volume | 6 |
| Pages | 61-61 |
| Publication date | 2015-05-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2015.00061 |
| PMID | 25999864 |
| PMCID | PMC4418274 |
| OpenAlex | W1604328968 |
| Language | EN |
| References cited | 7 |
The main objective of this preliminary study was to further clarify the association between testosterone (T) levels and depression by investigating symptom-based depression subtypes in a sample of 64 men. The data were taken from the ZInEP epidemiology survey. Gonadal hormones of a melancholic (n = 25) and an atypical (n = 14) depression subtype, derived from latent class analysis, were compared with those of healthy controls (n = 18). Serum T was assayed using an enzyme-linked immunosorbent assay procedure. Analysis of variance, analysis of covariance, non-parametrical tests, and generalized linear regression models were performed to examine group differences. The atypical depressive subtype showed significantly lower T levels compared with the melancholic depressives. While accumulative evidence indicates that, beyond psychosocial characteristics, the melancholic and atypical depressive subtypes are also distinguishable by biological correlates, the current study expanded this knowledge to include gonadal hormones. Further longitudinal research is warranted to disclose causality by linking the multiple processes in pathogenesis of depression
Depression (economics · Psychiatry · Testosterone (patch · Clinical Psychology · Hormonal and reproductive studies · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Internal Medicine
| Highly cited | No |
|---|