Testosterone, Gonadotropin, and Cortisol Secretion in Male Patients With Major Depression
Bibliographic Data
| ID | 19308308 |
|---|---|
| Authors | Ulrich Schweiger (0000-0001-9807-0979, Max Planck Institute of Psychiatry), Michael Deuschle (0000-0001-5038-1137, University of Lübeck), Bettina Weber (0000-0002-5453-3967, University of Lübeck), Andreas Körner (0000-0001-7116-1707, University of Lübeck), Claas-Hinrich Lammers, Claas‐Hinrich Lammers (University of Lübeck), Jurgen Schmider (University of Lübeck), Ulrike Gotthardt, Isabella Heuser (0000-0001-7075-1158, University of Lübeck) |
| Year | 1999 |
| Volume | 61 |
| Issue | 3 |
| Pages | 292-296 |
| Publication date | 1999-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-199905000-00007 |
| PMID | 10367608 |
| OpenAlex | W2085461121 |
| Language | EN |
| Citations received | 5 |
| References cited | 24 |
OBJECTIVE: Previous studies of sex hormone concentrations in depression yielded inconsistent results. However, the activation of the hypothalamic-pituitary-adrenal system seen in depression may negatively affect gonadal function at every level of regulation. The objective of this study was to explore whether major depressive episodes are indeed associated with an alteration of gonadal function. METHODS: Testosterone, pulsatile LH secretion, FSH, and cortisol were assessed using frequent sampling during a 24-hour period in 15 male inpatients with major depression of moderate to high severity and in 22 healthy comparison subjects (age range 22-85 years). RESULTS: An analysis of covariance model showed that after adjustment for age only, daytime testosterone (p < .01), nighttime testosterone (p < .05), and 24-hour mean testosterone secretion (p < .01) were significantly lower in the depressed male inpatients. There was also a trend for a decreased LH pulse frequency in the depressed patients (p < .08). CONCLUSIONS: Gonadal function may be disturbed in men with a depressive episode of moderate to high severity
Depression (economics) · Gonadotropin · Hormone · Hydrocortisone · Hypothalamic–pituitary–gonadal axis · Luteinizing hormone · Major depressive episode · Pulsatile flow · Testosterone (patch) · Endocrinology · Hormonal and reproductive studies · Hypothalamic control of reproductive hormones · Internal Medicine · Medicine · Psychology · Stress Responses and Cortisol
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Hypercortisolemic Depression Is Associated With Increased Intra-Abdominal Fat
| Citations per year | 0.21 |
|---|---|
| Citation span | 2002 - 2020 (19) |
| Highly cited | No |