Impulsivity and Venturesomeness in an Adult ADHD Sample
Relation to Personality, Comorbidity, and Polygenic Risk
Bibliographic Data
| ID | 15517533 |
|---|---|
| Authors | O Grimm (0000-0002-0767-0301, Goethe University Frankfurt, corresponding author), Heike Weber (0000-0002-9421-1292, Goethe University Frankfurt), Sarah Kittel‐Schneider (0000-0003-3057-6150, Goethe University Frankfurt), Sarah Kittel-Schneider, Thorsten M Kranz (0000-0002-7233-9308, Goethe University Frankfurt), Christian Jacob (0000-0003-2475-4205), Christian P Jacob, Klaus-Peter Lesch (0000-0001-8348-153X), Andreas Reif (0000-0002-0992-634X, Goethe University Frankfurt) |
| Year | 2020 |
| Volume | 11 |
| Pages | 557160-557160 |
| Publication date | 2020-12-14 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.557160 |
| PMID | 33381055 |
| OpenAlex | W3110917196 |
| Language | EN |
| Citations received | 1 |
| References cited | 51 |
While impulsivity is a basic feature of attention-deficit/hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Venturesomeness, unlike immediate Impulsivity, is not specific to ADHD. We consequently analyzed the influence of Imp and Vent also in the context of a PRS on psychiatric comorbidities of ADHD. Vent shows a distinctly different distribution of comorbidities, e.g., less anxiety and depression. PRS showed no effect on different ADHD comorbidities, but correlated with childhood hyperactivity. In a complementary analysis using principal component analysis with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition ADHD criteria, revised NEO Personality Inventory, Imp, Vent, and PRS, we identified three ADHD subtypes. These are an impulsive-neurotic type, an adventurous-hyperactive type with a stronger genetic component, and an anxious-inattentive type. Our study thus suggests the importance of adventurousness and the differential consideration of impulsivity in ADHD. The genetic risk is distributed differently between these subtypes, which underlines the importance of clinically motivated subtyping. Impulsivity subtyping might give insights into the organization of comorbid disorders in ADHD and different genetic background
Anxiety · Comorbidity · Context (archaeology · Impulsivity · Personality · Psychiatry · Sensation Seeking · Subtyping · Attention Deficit Hyperactivity Disorder · Bipolar Disorder and Treatment · Clinical Psychology · Functional Brain Connectivity Studies · Psychology
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Principal component analysis
The Prevalence of DSM-IV Attention-Deficit/Hyperactivity Disorder
Clinical use of current polygenic risk scores may exacerbate health disparities
Basic principles of ROC analysis
Fifty years of the Barratt Impulsiveness Scale
Impulsiveness and Venturesomeness
Functional and dysfunctional impulsivity
Drugs and the law
On inhibition/disinhibition in developmental psychopathology
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |