Altered Interoceptive Processing in Generalized Anxiety Disorder—A Heartbeat-Evoked Potential Research
Bibliographic Data
| ID | 15517539 |
|---|---|
| Authors | Jiaoyan Pang (Shanghai Mental Health Center), Xiaochen Tang (0000-0003-3796-7111, Shanghai Mental Health Center), Hui Li (0000-0001-9355-1116, Shanghai Jiao Tong University), Qiang Hu (0000-0001-8359-5764, Shanghai Jiao Tong University), Huiru Cui (0000-0001-5171-1871, Shanghai Jiao Tong University), Lanlan Zhang (0000-0003-0246-9841, Suzhou Guangji Hospital), Wei Li (0000-0002-3581-849X, Shanghai Mental Health Center), Zhuoying Zhu (0000-0002-8865-9218, Shanghai Jiao Tong University), Jijun Wang (0000-0003-4536-9664, Institute of Psychology, Chinese Academy of Sciences, corresponding author), Chunbo Li (0000-0002-3387-4439, Center for Excellence in Brain Science and Intelligence Technology, corresponding author) |
| Year | 2019 |
| Volume | 10 |
| Pages | 616-616 |
| Publication date | 2019-09-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00616 |
| PMID | 31543837 |
| OpenAlex | W2965633253 |
| Language | EN |
| Citations received | 2 |
| References cited | 9 |
Generalized anxiety disorder (GAD) is one of the most common anxiety disorders. The brain's dysfunctional processing of interoceptive information is increasingly recognized as an important component of anxiety disorders. However, the neural mechanisms remain insufficiently understood. In the present study, patients with GAD and healthy control participants underwent an eyes-closed (EC) resting state (interoception) and eyes-open (EO) resting state (exteroception) without paying conscious attention to heartbeat. Electrocardiography (ECG) and electroencephalography (EEG) signals were recorded at the same time. The results show that in healthy controls, the heartbeat-evoked brain potential (HEP) was modulated by the conditions, with a significantly higher amplitude under EC than EO, while this was not the case in GAD patients. Further analysis revealed that the dysfunction of HEP modulation in GAD patients may be attributed to excessive interoceptive processing under EO, with a marginally higher HEP in GAD than in the healthy controls. Finally, the right prefrontal HEP amplitude during EC condition was significantly correlated with the severity of the patients' anxiety symptoms. Our results suggest that altered cortical processing of interoceptive signals may play an important role in the pathophysiology of generalized anxiety disorder
Anxiety · Audiology · Electroencephalography · Generalized anxiety disorder · Heartbeat · Interoception · Panic disorder · Perception · Psychiatry · Resting state fMRI · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Psychosomatic Disorders and Their Treatments
Heart Beat Perception and Emotional Experience
Interoception and Mental Health
Adaptive linear step-up procedures that control the false discovery rate
Nonparametric statistical testing of EEG- and MEG-data
A Rating Scale for Depression
Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder
From cognitivism to autopoiesis
The Assessment of Anxiety States by Rating
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2022 - 2025 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |