Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects
Between Compensation and Resilience
Bibliographic Data
| ID | 15518338 |
|---|---|
| Authors | Bianca Besteher (0000-0001-7989-9298, Jena University Hospital), Letizia Squarcina (0000-0001-6209-4629, IRCCS Eugenio Medea), Robert Spalthoff (0000-0002-6992-9235, Jena University Hospital), Marcella Bellani (0000-0003-1727-5396, Azienda Ospedaliera Universitaria Integrata Verona), Christian Gaser (0000-0002-9940-099X, Jena University Hospital), Igor Nenadic (0000-0002-0749-7473, Center for Behavioral Brain Sciences, corresponding author), Paolo Brambilla (0000-0002-4021-8456, University of Milan) |
| Year | 2018 |
| Volume | 9 |
| Pages | 541-541 |
| Publication date | 2018-11-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00541 |
| PMID | 30546323 |
| OpenAlex | W2902045562 |
| Language | EN |
| Citations received | 1 |
| References cited | 6 |
Background: Symptoms of anxiety are present not only in panic disorder or other anxiety disorders, but are highly prevalent in the general population. Despite increasing biological research on anxiety disorders, there is little research on understanding subclinical or sub-threshold symptoms relating to anxiety in non-clinical community samples, which could give clues to factors relating to resilience or compensatory changes. Aims: This study focused on brain structural correlates of subclinical anxiety/agoraphobia symptoms from a multi-center imaging study. Methods: We obtained high-resolution structural T1 MRI scans of 409 healthy young participants and used the CAT12 toolbox for voxel-based morphometry (VBM) analysis. Subjects provided self-ratings of anxiety using the SCL-90-R, from which we used the phobia subscale, covering anxiety symptoms related to those of panic and agoraphobia spectrum. Results: We found significant ( p Conclusions: Our findings show brain structural associations of subclinical symptoms of anxiety, which overlap with those seen in panic disorder or agoraphobia. This is consistent with a dimensional model of anxiety, which is reflected not only functionally but also on the structural level
Agoraphobia · Anxiety · Cognition · Generalized anxiety disorder · Magnetic resonance imaging · Orbitofrontal cortex · Panic · Panic disorder · Population · Prefrontal cortex · Psychiatry · Specific phobia · Subclinical infection · Voxel-based morphometry · White matter · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Mental Health Research Topics · Psychology · Internal Medicine
| Citations per year | 0.14 |
|---|---|
| Citation span | 2019 - 2019 (1) |
| Highly cited | No |