Hippocampal Volume as a Putative Marker of Resilience or Compensation to Minor Depressive Symptoms in a Nonclinical Sample
Bibliographic Data
| ID | 15518682 |
|---|---|
| Authors | Bianca Besteher (0000-0001-7989-9298, Jena University Hospital), Letizia Squarcina (0000-0001-6209-4629, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Robert Spalthoff (0000-0002-6992-9235, Jena University Hospital), Marcella Bellani (0000-0003-1727-5396, University of Verona), Christian Gaser (0000-0002-9940-099X, Jena University Hospital), Paolo Brambilla (0000-0002-4021-8456, University of Milan), Igor Nenadic (0000-0002-0749-7473, Universitätsklinikum Gießen und Marburg, corresponding author) |
| Year | 2019 |
| Volume | 10 |
| Pages | 467-467 |
| Publication date | 2019-07-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00467 |
| PMID | 31354542 |
| OpenAlex | W2951980495 |
| Language | EN |
| References cited | 34 |
Case-control studies in major depression have established patterns of regional gray matter loss, including the hippocampus, which might show state-related effects dependent on disease stage. However, there is still limited knowledge on compensation effects that might occur in people resilient to depression showing only subclinical symptoms. We used voxel-based morphometry on a multicenter data set of 409 healthy nonclinical subjects to test the hypothesis that local hippocampal volume would be inversely correlated with subclinical depressive symptoms [Symptom Checklist 90-Revised (SCL-90-R) depression scores]. Our region-of-interest results show a significant ( p = 0.042, FWE cluster-level corrected) positive correlation of SCL-90-R scores for depression and a left hippocampus cluster. Additionally, we provide an exploratory finding of gyrification, a surface-based morphometric marker, correlating with a right postcentral gyrus cluster [ p = 0.031, family-wise error (FWE) cluster-level corrected]. Our findings provide first preliminary evidence of an inverse relationship for subjects in the absence of clinical depression and might thus point to processes related to compensation. Similar effects have been observed in remission from major depression and thus deserve further study to evaluate hippocampal volume not only as a state-dependent marker of disease but also of resilience
Audiology · Cerebral cortex · Depression (economics · Grey matter · Gyrification · Hippocampal formation · Hippocampus · Magnetic resonance imaging · Psychiatry · Radiology · Subclinical infection · Voxel · Voxel-based morphometry · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Internal Medicine
| Highly cited | No |
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