Alterations in the Plasma Lipidome of Adult Women With Bipolar Disorder
A Mass Spectrometry-Based Lipidomics Research
Bibliographic Data
| ID | 15518629 |
|---|---|
| Authors | Lin Guo (0000-0002-5415-7850), Ting Zhang (0000-0002-6840-1367), Rui Li (0000-0001-9744-7965), Zhi-quan Cui, Jing Du (0000-0002-6767-2763), Jia-bin Yang, Fen Xue (0000-0002-9329-9472, Xijing Hospital), Yihuan Chen (0000-0002-9441-4997, Air Force Medical University), Yi-Huan Chen, Qihua Tan (0000-0003-3194-0030, corresponding author), Qing-rong Tan, Zhengwu Peng (0000-0002-8185-0538, Air Force Medical University, corresponding author), Zheng-wu Peng |
| Year | 2022 |
| Volume | 13 |
| Pages | 802710-802710 |
| Publication date | 2022-03-21 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.802710 |
| PMID | 35386518 |
| OpenAlex | W4220904566 |
| Language | EN |
| Citations received | 2 |
| References cited | 71 |
Lipidomics has become a pivotal tool in biomarker discovery for the diagnosis of psychiatric illnesses. However, the composition and quantitative analysis of peripheral lipids in female patients with bipolar disorder (BD) have been poorly addressed. In this study, plasma samples from 24 female patients with BD and 30 healthy controls (HCs) were analyzed by comprehensive lipid profiling and quantitative validation based on liquid chromatography-mass spectrometry. Clinical characteristics and a correlation between the level of lipid molecules and clinical symptoms were also observed. We found that the quantitative alterations in several lipid classes, including acylcarnitine, lysophosphatidylethanolamine, GM2, sphingomyelin, GD2, triglyceride, monogalactosyldiacylglycerol, phosphatidylinositol phosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylethanolamine, phosphatidylserine, and lysophosphatidylinositol, were remarkably upregulated or downregulated in patients with BD and were positively or negatively correlated with the severity of psychotic, affective, or mania symptoms. Meanwhile, the composition of different carbon chain lengths and degrees of fatty acid saturation for these lipid classes in BD were also different from those of HCs. Moreover, 55 lipid molecules with significant differences and correlations with the clinical parameters were observed. Finally, a plasma biomarker set comprising nine lipids was identified, and an area under the curve of 0.994 was obtained between patients with BD and the HCs. In conclusion, this study provides a further understanding of abnormal lipid metabolism in the plasma and suggests that specific lipid species can be used as complementary biomarkers for the diagnosis of BD in women
Bipolar disorder · Chromatography · DSM-5 · Lipidome · Lipidomics · Lithium (medication · Mass spectrometry · Psychiatry · Bipolar Disorder and Treatment · Chemistry · Clinical Psychology · Electrolyte and hormonal disorders · Medicine · Psychology · Tryptophan and brain disorders · Biochemistry
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| Unique citing works | 2 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2022 - 2023 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |