Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression
Bibliographic Data
| ID | 15517859 |
|---|---|
| Authors | Ting Zhang (0000-0002-6840-1367), Lin Guo (0000-0002-5415-7850), Rui Li (0000-0001-9744-7965), Fei Wang (0000-0003-0860-6317), Wenmao Yang, Wen-mao Yang, Jia-bin Yang, Zhi-quan Cui, Cuihong Zhou (0000-0002-2088-0258, Air Force Medical University), Cui-hong Zhou, Yihuan Chen (0000-0002-9441-4997, Air Force Medical University), Yi-Huan Chen, Huan Yu (0009-0009-0408-3804, Xijing Hospital), Zhengwu Peng (0000-0002-8185-0538, Xijing Hospital, corresponding author), Zheng-wu Peng, Qihua Tan (0000-0003-3194-0030, corresponding author), Qing-rong Tan |
| Year | 2022 |
| Volume | 13 |
| Pages | 927817-927817 |
| Publication date | 2022-07-18 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.927817 |
| PMID | 35923457 |
| OpenAlex | W4285728934 |
| Language | EN |
| Citations received | 1 |
| References cited | 89 |
Lipidomics has been established as a potential tool for the investigation of mental diseases. However, the composition analysis and the comparison of the peripheral lipids regarding adult women with major depressive depression (MDD) or bipolar depression (BPD) has been poorly addressed. In the present study, age-matched female individuals with MDD ( n = 28), BPD ( n = 22) and healthy controls (HC, n = 25) were enrolled. Clinical symptoms were assessed and the plasma samples were analyzed by comprehensive lipid profiling based on liquid chromatography-mass spectrometry (LC/MS). We found that the composition of lipids was remarkably changed in the patients with MDD and BPD when compared to HC or compared to each other. Moreover, we identified diagnostic potential biomarkers comprising 20 lipids that can distinguish MDD from HC (area under the curve, AUC = 0.897) and 8 lipids that can distinguish BPD from HC (AUC = 0.784), as well as 13 lipids were identified to distinguish MDD from BPD with moderate reliability (AUC = 0.860). This study provides further understanding of abnormal lipid metabolism in adult women with MDD and BPD and may develop lipid classifiers able to effectively discriminate MDD from BPD and HC
Bioinformatics · Biology · Bipolar disorder · Cognition · Depression (economics · Lipidomics · Lithium (medication · Major depressive disorder · Psychiatry · Bipolar Disorder and Treatment · Clinical Psychology · Diet and metabolism studies · Medicine · Psychology · Tryptophan and brain disorders · Endocrinology · Internal Medicine · Oncology
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Alterations in the Plasma Lipidome of Adult Women With Bipolar Disorder
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |