Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
Bibliographic Data
| ID | 15518782 |
|---|---|
| Authors | Jiang Long (0000-0001-6571-0589, Sichuan University), Jinping Xu (0000-0002-1429-2783, Chinese Academy of Sciences), Xue Wang (0009-0005-0215-9044, Sichuan University), Jin Li (0000-0001-9004-715X, West China Hospital of Sichuan University), Shan Rao (West China Hospital of Sichuan University), Huawang Wu (0000-0003-3544-7374, Guangzhou Medical University, corresponding author), Weihong Kuang (0000-0002-3708-4987, Sichuan University, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 585401-585401 |
| Publication date | 2020-12-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.585401 |
| PMID | 33424661 |
| OpenAlex | W3111651141 |
| Language | EN |
| Citations received | 1 |
| References cited | 45 |
A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression
Abnormality · Cerebral cortex · Cognition · Disease · Fusiform gyrus · Gyrification · Magnetic resonance imaging · Major depressive disorder · Neuropathology · Precentral gyrus · Psychiatry · Advanced Neuroimaging Techniques and Applications · Atomic and Subatomic Physics Research · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Internal Medicine
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |