Altered Brain Function in Drug-Naïve Major Depressive Disorder Patients With Early-Life Maltreatment
A Resting-State fMRI Study
Bibliographic Data
| ID | 15519197 |
|---|---|
| Authors | Zhexue Xu (Xuan Wu Hospital of the Capital Medical University), Jing Zhang (0000-0002-6431-9286, Xuan Wu Hospital of the Capital Medical University), Di Wang (0000-0002-7338-3351, Beijing Anding Hospital), Ting Wang (0000-0003-3792-1260, Nanjing Traditional Chinese Medicine Hospital), Shu Zhang (0009-0008-6739-1356, Beijing Fengtai Hospital), Xi Ren (0000-0003-4814-5260, Beijing University of Chinese Medicine), Xiaolei Zhu (0000-0003-4696-9696, Johns Hopkins Medicine), Atsushi Kamiya (0000-0002-4274-5567, Johns Hopkins University), Jiliang Fang (0000-0002-6202-0678, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Miao Qu (0000-0001-6289-9654, Beijing University of Chinese Medicine, corresponding author) |
| Year | 2019 |
| Volume | 10 |
| Pages | 255-255 |
| Publication date | 2019-04-24 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00255 |
| PMID | 31068844 |
| OpenAlex | W2941707751 |
| Language | EN |
| Citations received | 1 |
| References cited | 54 |
Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience
Brain function · Drug · Drug-naïve · Major depressive disorder · Mood · Psychiatry · Resting state fMRI · Substance abuse · Child Abuse and Trauma · Clinical Psychology · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Mental Health Treatment and Access · Neuroscience · Psychology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |