Accelerated Brain Aging in Patients With Obsessive-Compulsive Disorder
Datos Bibliográficos
| ID | 15519461 |
|---|---|
| Autores | Liang Liu (0000-0003-1372-4596, First Affiliated Hospital of Zhengzhou University), Junhong Liu (0000-0001-9786-7601, First Affiliated Hospital of Zhengzhou University), Li Yang (0000-0003-3852-3651), Yang Li (0000-0002-2835-6661, Huanghuai University), Baohong Wen (0000-0003-4566-7565, First Affiliated Hospital of Zhengzhou University, autor de correspondencia), Xiaopan Zhang (0000-0003-3303-7363, First Affiliated Hospital of Zhengzhou University), Junying Cheng (0000-0002-8871-9612, First Affiliated Hospital of Zhengzhou University, autor de correspondencia), Shaoqiang Han (0000-0001-7331-0315, First Affiliated Hospital of Zhengzhou University, autor de correspondencia), Yong Zhang (0000-0001-6711-5791, First Affiliated Hospital of Zhengzhou University, autor de correspondencia), Jingliang Cheng (0000-0001-9944-8419, First Affiliated Hospital of Zhengzhou University) |
| Año | 2022 |
| Volumen | 13 |
| Páginas | 852479-852479 |
| Fecha de publicación | 2022-05-06 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.852479 |
| PMID | 35599767 |
| OpenAlex | W4229040594 |
| Idioma | EN |
| Citas recibidas | 2 |
| Referencias citadas | 48 |
Obsessive-compulsive disorder (OCD) may be accompanied by an accelerated structural decline of the brain with age compared to healthy controls (HCs); however, this has yet to be proven. To answer this question, we built a brain age prediction model using mean gray matter volumes of each brain region as features, which were obtained by voxel-based morphometry derived from T1-weighted MRI scans. The prediction model was built using two Chinese Han datasets (dataset 1, N = 106 for HCs and N = 90 for patients with OCD; dataset 2, N = 270 for HCs) to evaluate its performance. Then, a new prediction model was trained using data for HCs in dataset 1 and applied to patients with OCD to investigate the brain aging trajectory. The brain-predicted age difference (brain-PAD) scores, defined as the difference between predicted brain age and chronological age, were calculated for all participants and compared between patients with matched HCs in dataset 1. It was demonstrated that the prediction model performs consistently across different datasets. Patients with OCD presented higher brain-PAD scores than matched HCs, suggesting that patients with OCD presented accelerated brain aging. In addition, brain-PAD scores were negatively correlated with the duration of illness, suggesting that brain-PAD scores might capture progressive structural brain changes. These results identified accelerated brain aging in patients with OCD for the first time and deepened our understanding of the pathogenesis of OCD
Audiology · Brain aging · Brain size · Cognition · Magnetic resonance imaging · Neuroimaging · Obsessive compulsive · Psychiatry · Radiology · Voxel · Voxel-based morphometry · White matter · Autism Spectrum Disorder Research · Eating Disorders and Behaviors · Medicine · Obsessive-Compulsive Spectrum Disorders · Psychology · Internal Medicine
| Obras citantes distintas | 2 |
|---|---|
| Citas por año | 1 |
| Intervalo de citas | 2024 - 2024 (1) |
| Velocidad de citación | recent |
| Altamente citado | No |
| Tipos de cita | Neutras: 2 |