Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-Fubinaca, Cumyl-Pinaca, PB-22, and XLR-11
Bibliographic Data
| ID | 15519967 |
|---|---|
| Authors | Richard C Kevin (0000-0002-4912-4499, The University of Sydney, corresponding author), Elizabeth A Cairns (0000-0002-9816-4761, The University of Sydney), Rochelle Boyd (0000-0001-7535-1815, The University of Sydney), Jonathon C Arnold (0000-0002-0159-9997, The University of Sydney), Michael T Bowen (0000-0002-8965-4136, The University of Sydney), Iain S McGregor (0000-0002-9307-7159, The University of Sydney), Samuel D Banister (0000-0002-4690-4318, The University of Sydney) |
| Year | 2022 |
| Volume | 13 |
| Pages | 1048836-1048836 |
| Publication date | 2022-12-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.1048836 |
| PMID | 36590635 |
| OpenAlex | W4311510816 |
| Language | EN |
| Citations received | 1 |
| References cited | 46 |
These results suggest that while some "off-targets" could possibly contribute to the SCRA toxidrome, particularly at high concentrations, CB1-mediated cellular dysfunction provides support for hypotheses concerning on-target, rather than off-target, toxicity. Further investigation of non-GPCR off-targets is warranted
Agonist · Biology · Cannabinoid · Cannabinoid receptor · Cannabinoid Receptor Agonists · Cannabinoid receptor type 2 · G protein-coupled receptor · Inverse agonist · Receptor · Synthetic cannabinoids · Cannabis and Cannabinoid Research · Chemistry · Forensic Toxicology and Drug Analysis · Neurotransmitter Receptor Influence on Behavior · Biochemistry · Pharmacology
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |