Alterations in coupling between global brain activity and cerebrospinal fluid flow in patients with insomnia disorder before and after transcranial direct current stimulation

A resting-state functional MRI study

Bibliographic Data

ID15520259
AuthorsDehong Liu (0000-0003-3355-3018, Jilin University), Xin Chen (0000-0001-7221-0056, Jilin University), Xiaotong Zhang (0000-0002-9197-1421, Jilin University), Jiaqi Peng (0000-0001-7743-4518, Jilin University), Hong-Wei Zhou (0000-0003-1771-6905), Hongwei Zhou (0000-0003-2472-8541, Jilin University), Wenjing Lan (Jilin University, corresponding author)
Year2025
Volume16
Pages1705101-1705101
Publication date2025-12-18
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1705101
PMID41488559
OpenAlexW4417450282
LanguageEN
References cited57

Our results indicate that IDs exhibit impaired glymphatic system function, as reflected by reduced gBOLD-CSF coupling strength. This reduction was correlated with the severity of both insomnia and anxiety symptoms. Moreover, we demonstrated that tDCS can not only improve symptoms of insomnia, anxiety, and depression but also enhance glymphatic activity in IDs

Anxiety · Brain activity and meditation · Cerebral blood flow · Cerebrospinal fluid · Coupling (piping · Depression (economics · Glymphatic system · Insomnia · Cerebrospinal fluid and hydrocephalus · Epilepsy research and treatment · Neurological disorders and treatments

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