Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence
Bibliographic Data
| ID | 15520433 |
|---|---|
| Authors | Ming-Chyi Huang, Ming‐Chyi Huang (0000-0001-9751-9834, Taipei City Hospital), Lian-Yu Chen, Lian‐Yu Chen (0000-0001-9241-1613, Taipei City Hospital), Hu‐Ming Chang (0000-0001-7616-8529, Taipei City Hospital), Hu-Ming Chang, Xiaoyu Liang (0000-0001-7796-2441, Yale University), Xiao-Yu Liang, Chih‐Ken Chen (0000-0003-1921-8870, Chang Gung University, corresponding author), Chih-Ken Chen, Wan-Ju Cheng, Wan‐Ju Cheng (0000-0003-4510-7584, China Medical University, corresponding author), Ke Xu (0000-0003-3883-5268, Yale University) |
| Year | 2018 |
| Volume | 9 |
| Pages | 633-633 |
| Publication date | 2018-11-26 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00633 |
| PMID | 30534093 |
| OpenAlex | W2902065655 |
| Language | EN |
| Citations received | 2 |
| References cited | 28 |
Background: Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a common drug of abuse worldwide. Existing evidence suggest a disruption of oxytocin system involves in the development of addiction. In this study, we aimed to investigate the role of oxytocin in ketamine addiction by measuring the blood oxytocin levels in ketamine-dependent (KD) patients. Methods: Sixty-five KD patients and 65 controls were enrolled. Fasting plasma levels of oxytocin were determined at baseline and 1 and 2 weeks after ketamine withdrawal. Ketamine use variables, Beck Depression Inventory, Beck Anxiety Inventory (BAI), Visual Analog Scale for craving, and Childhood Trauma Questionnaire-short form were assessed in KD patients. Results: KD patients had significantly lower levels of oxytocin at baseline compared to controls (5.89 ± 2.13 vs. 9.53 ± 4.17 ng/mL, P P P = 0.01) of withdrawal in KD patient despite the levels were still lower than controls ( P = 0.001 and 0.002, respectively). The clinical variables did not correlate with baseline oxytocin levels except BAI scores, which showed a negative correlation with the levels ( r = -0.263; P = 0.039). Conclusion: We found a distinctively reduced oxytocin level in KD patients and the level did not normalize after early abstinence. Lower oxytocin might be associated with anxious phenotype of ketamine dependence. These results suggest that oxytocin system dysregulated following chronic ketamine abuse and might provide insight in evaluating the potential therapeutic use of oxytocin for treating ketamine dependence
Abstinence · Anesthesia · Ketamine · Oxytocin · Psychiatry · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroendocrine regulation and behavior · Prenatal Substance Exposure Effects · Psychology · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,4 |
| Citation span | 2021 - 2021 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |