Modulation of cortical functional connectivity and spectrum with transcranial focused ultrasound in chronic disorders of consciousness

A case report

Bibliographic Data

ID15520705
AuthorsShu Cheng (0000-0001-7077-4165, Kunming Medical University, corresponding author), Xuan Xu (0000-0002-7913-3599, Kunming Medical University), Lei (0000-0002-1706-0179), Lei Lei (0000-0002-3366-1855, Chinese University of Hong Kong), Fanyuan Meng (0000-0002-7825-8509, Kunming Medical University), Xiaojing Long (0000-0003-4455-7831, Chinese Academy of Sciences), Qihui Liang (National Rehabilitation Center), Kaixuan Luo (0000-0003-1515-5737, Kunming Medical University), Xiangjun Feng (0000-0003-3971-2702, Kunming Medical University), Moxian Chen (Kunming Medical University), Lijuan Ao (0000-0002-5788-2062, Kunming Medical University)
Year2026
Volume17
Pages1748927-1748927
Publication date2026-02-18
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2026.1748927
PMID41788646
OpenAlexW7130342484
LanguageEN
References cited30

This case provides cohesive, multi-modal evidence suggesting that targeted thalamic tFUS may be associated with a restorative process, concurrent with the normalization of dysfunctional cortical rhythms and the reintegration of large-scale brain networks that parallel the recovery of consciousness. Our findings offer preliminary insights supporting the continued investigation of tFUS as a potential therapeutic strategy for patients with severe brain injury

Electroencephalography · Focused ultrasound · Minimally conscious state · Neuroimaging · Neuromodulation · Neurophysiology · Persistent vegetative state · Prefrontal cortex · Thalamus · Transcranial magnetic stimulation · Transcranial Magnetic Stimulation Studies · Traumatic Brain Injury Research · Ultrasound and Hyperthermia Applications

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