Lower Levels of Gabaergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression
Bibliographic Data
| ID | 15522339 |
|---|---|
| Authors | Hyunjung Oh (0000-0003-2218-1896, Mental Health Research Canada, corresponding author), Dwight F Newton (0000-0002-5460-8033, Mental Health Research Canada), Dwight Newton, David Lewis (0000-0002-0253-5530), David A Lewis (0000-0002-5534-8392, University of Pittsburgh), Etienne Sibille (0000-0001-5832-6570, University of Toronto, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 827972-827972 |
| Publication date | 2022-02-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.827972 |
| PMID | 35280164 |
| OpenAlex | W4214487104 |
| Language | EN |
| References cited | 109 |
CRH+ cells in human sgACC are a heterogeneous population of GABAergic interneurons, although largely co-expressing VIP. Our data suggest that MDD is associated with reduced markers of inhibitory function in sgACC CRH+ interneurons, and provide further evidence for impaired GABAergic function in the cortex in MDD
Amygdala · Anterior cingulate cortex · Biology · Cognition · Corticotropin-releasing hormone · GABAergic · Gene · Gene expression · Hypothalamus · Inhibitory postsynaptic potential · Interneuron · Major depressive disorder · Neurotrophic factors · Receptor · Transcriptome · Hormonal Regulation and Hypertension · Medicine · Neuroscience · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Genetics · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |