Advanced Age Is Associated With Catatonia in Critical Illness

Results From the Delirium and Catatonia Prospective Cohort Investigation

Bibliographic Data

ID15522981
AuthorsJennifer Connell (0000-0002-9433-249X, Vanderbilt University), Ahra Kim (0000-0001-5415-5145, Vanderbilt University Medical Center), Nathan E Brummel (0000-0003-4308-0015, The Ohio State University Wexner Medical Center), Mayur B Patel (0000-0001-5230-0871, Geriatric Research Education and Clinical Center), Simon Vandekar (0000-0002-7457-9073, Vanderbilt University Medical Center), Simon N Vandekar, Pratik P Pandharipande (0000-0002-1389-8580, Vanderbilt University Medical Center), Pratik Pandharipande, Robert S Dittus (VA Tennessee Valley Healthcare System), Stephan Heckers (0000-0003-3601-9910, Vanderbilt University Medical Center), E Wes Ely (Geriatric Research Education and Clinical Center), Jo Ellen Wilson (0000-0003-2565-8012, Vanderbilt University Medical Center, corresponding author)
Year2021
Volume12
Pages673166-673166
Publication date2021-11-19
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.673166
PMID34867501
OpenAlexW3216946600
LanguageEN
Citations received1
References cited22

Introduction: Catatonia, characterized by motor, behavioral and affective abnormalities, frequently co-occurs with delirium during critical illness. Advanced age is a known risk factor for development of delirium. However, the association between age and catatonia has not been described. We aim to describe the occurrence of catatonia, delirium, and coma by age group in a critically ill, adult population. Design: Convenience cohort, nested within two clinical trials and two observational cohort studies. Setting: Intensive care units in an academic medical center in Nashville, TN. Patients: 378 critically ill adult patients on mechanical ventilation and/or vasopressors. Measurements and Main Results: Patients were assessed for catatonia, delirium, and coma by independent and blinded personnel, the Bush Francis Catatonia Rating Scale, the Confusion Assessment Method for the Intensive Care Unit (ICU) and the Richmond Agitation and Sedation Scale. Of 378 patients, 23% met diagnostic criteria for catatonia, 66% experienced delirium, and 52% experienced coma during the period of observation. There was no relationship found between age and catatonia severity or age and presence of specific catatonia items. The prevalence of catatonia was strongly associated with age in the setting of critical illness ( p Conclusion: Given the significant relationship between age and catatonia independent of coma and delirium status, these data demonstrate catatonia's association with advanced age in the setting of critical illness. Future studies can explore the causative factors for this association and further elucidate the risk factors for acute brain dysfunction across the age spectrum

Anesthesia · Catatonia · Cohort · Delirium · Intensive care · Intensive care medicine · Intensive care unit · Population · Psychiatry · Schizophrenia (object-oriented programming · Sedation · Anesthesia and Neurotoxicity Research · Anesthesia and Sedative Agents · Intensive Care Unit Cognitive Disorders · Medicine · Psychology · Internal Medicine · Pediatrics

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