The Promises and Pitfalls of Retrieval-Extinction Procedures in Preventing Relapse to Drug Seeking

Bibliographic Data

ID15523716
AuthorsKate Hutton-Bedbrook (UNSW Sydney, corresponding author), Gavan P McNally (0000-0001-9061-6463, UNSW Sydney)
Year2013
Volume4
Pages14-14
Publication date2013-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2013.00014
PMID23487003
PMCIDPMC3594919
OpenAlexW2161573874
LanguageEN
Citations received3
References cited1

Relapse to drug seeking after treatment or a period of abstinence remains a fundamental challenge for drug users. The retrieval - extinction procedure offers promise in augmenting the efficacy of exposure based treatment for drug use and for protecting against relapse to drug seeking. Preceding extinction training with a brief retrieval or reminder trial, retrieval - extinction training, has been shown to reduce reinstatement of extinguished drug seeking in animal models and also to produce profound and long lasting decrements in cue-induced craving in human heroin users. However, the mechanisms that mediate these effects of retrieval - extinction training are unclear. Moreover, under some circumstances, the retrieval - extinction procedure can significantly increase vulnerability to reinstatement in animal models

Abstinence · Addiction · Biology · Craving · Drug · Extinction (optical mineralogy · Psychiatry · Psychotherapist · Relapse prevention · Vulnerability (computing · Computer Science · Medicine · Memory and Neural Mechanisms · Neuroscience and Neuropharmacology Research · Neurotransmitter Receptor Influence on Behavior · Psychology · Pharmacology

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