Amygdalar and Hippocampal Morphometry Abnormalities in First-Episode Schizophrenia Using Deformation-Based Shape Analysis
Bibliographic Data
| ID | 15523995 |
|---|---|
| Authors | Xiaoying Tang (0000-0002-9610-0318, Southern University of Science and Technology, corresponding author), Guiwen Lyu (Shenzhen University), Minhua Chen (0000-0003-0513-1301, Harbin Institute of Technology), Wei‐Kai Huang (Southern University of Science and Technology), Weikai Huang, Yin Lin (0009-0002-4786-1230, Shenzhen Children's Hospital) |
| Year | 2020 |
| Volume | 11 |
| Pages | 677-677 |
| Publication date | 2020-07-17 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.00677 |
| PMID | 32765318 |
| OpenAlex | W3043743424 |
| Language | EN |
| References cited | 57 |
In this study, we investigated and quantified the amygdalar and hippocampal morphometry abnormalities exerted by first-episode schizophrenia using a total of 92 patients and 106 healthy control participants. Magnetic resonance imaging (MRI) based automated segmentation was conducted to obtain the amygdalar and hippocampal segmentations. Disease-versus-control volume differences of the bilateral amygdalas and hippocampi were quantified. In addition, deformation-based statistical shape analysis was employed to quantify the region-specific shape abnormalities of each structure of interest. To better identify the key relevant areas in the pathology of first-episode schizophrenia, each structure was divided into four subregions; CA1, CA2, CA3 combined with dentate gyrus for the hippocampus in each hemisphere and basolateral, basomedial, centromedial, and lateral nucleus for the amygdala in each hemisphere. We observed significant global volume reduction and localized shape atrophy in each of the four structures of interest. The amygdalar shape abnormalities mainly occurred at the basolateral and centromedial subregions, whereas the hippocampal shape abnormalities mainly concentrated on the CA1 and CA2 subregions. For the same structure, the one on the right hemisphere was affected more by the disease pathology than that on the left hemisphere. To conclude, we have successfully quantified the global and local morphometric abnormalities of the bilateral amygdalas and hippocampi using a sophisticated statistical analysis pipeline and high-field subregion segmentations, with MRI data of a considerable sample size. This study is one of the very first of such kind in first-episode schizophrenia analyses
Amygdala · Atrophy · Brain morphometry · Dentate gyrus · Hippocampal formation · Hippocampus · Lateralization of brain function · Magnetic resonance imaging · Parahippocampal gyrus · Pathology · Psychiatry · Radiology · Schizophrenia (object-oriented programming · Temporal lobe · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment
| Citation velocity | historical |
|---|---|
| Highly cited | No |