Effect of gender-affirming treatments on depression and anxiety symptoms in transgender people
A retrospective cohort study
Bibliographic Data
| ID | 15524036 |
|---|---|
| Authors | C Shun Wong (0000-0001-6292-1188, Hospital Authority), Chun Yip Wong, Sze Ting Joanna Ngan (0009-0003-0493-1881, University of Hong Kong), Pak Wing Calvin Cheng (0000-0003-4457-1908, University of Hong Kong, corresponding author), Wing Ki Tang (Prince of Wales Hospital), Lai Yin Chow (Hong Kong Academy of Medicine), Wai Kwok Kam (Prince of Wales Hospital) |
| Year | 2026 |
| Volume | 16 |
| Pages | 1709778-1709778 |
| Publication date | 2026-01-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1709778 |
| PMID | 41561979 |
| OpenAlex | W7118165146 |
| Language | EN |
| References cited | 74 |
Gender-affirming medical treatments alone may not entirely resolve the mental health difficulties faced by transgender individuals. Future research needs to better elucidate the impacts of persistent psychosocial challenges such as discrimination and rejection, as well as potential treatment complications. The treatment-seeking nature of this cohort, coupled with baseline psychiatric interventions, may have obscured significant correlations. While gender-affirming treatments can enhance gender congruence, our findings highlight the importance of holistic approaches to strengthen adaptive buffering mechanisms throughout the gender transition process
Anxiety · Cohort study · Depression (economics · Mental health · Psychosocial · Retrospective cohort study · Transgender · Transgender Person · Gender Roles and Identity Studies · LGBTQ Health, Identity, and Policy · Sex and Gender in Healthcare
Endocrine Treatment of Transsexual Persons
Standards of Care for the Health of Transgender and Gender Diverse People, Version 8
Mental health and gender dysphoria
Social support and protection from depression
Depression Anxiety Stress Scales
Associations between minority stress, depression, and suicidal ideation and attempts in transgender and gender diverse (TGD) individuals
Assessing Chinese adolescents’ social support
Associations between loneliness and perceived social support and outcomes of mental health problems
Stress Generation, Avoidance Coping, and Depressive Symptoms
Anxiety and depression in transgender individuals
Long-Term Follow-Up of Transsexual Persons Undergoing Sex Reassignment Surgery
A systematic review of social stress and mental health among transgender and gender non-conforming people in the United States
A conceptual framework for clinical work with transgender and gender nonconforming clients
You want to measure coping but your protocol’ too long
Transpeople, Transprejudice and Pathologization
Effects of Medical Interventions on Gender Dysphoria and Body Image
A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people
Intervenable factors associated with suicide risk in transgender persons
Prevalence of anxiety symptoms and disorders in the transgender population
Social support, trans community connectedness, and mental health symptoms among transgender and gender nonconforming adults
The role of gender affirmation in psychological well-being among transgender women
Family Rejection, Social Isolation, and Loneliness as Predictors of Negative Health Outcomes (Depression, Suicidal Ideation, and Sexual Risk Behavior) Among Thai Male-to-Female Transgender Adolescents
Gender-Related Victimization, Perceived Social Support, and Predictors of Depression Among Transgender Australians
Transgender Youth and Social Support
An Evidence‐Based Model for Understanding the Mental Health Experiences of Transgender Australians
Social Support, Exposure to Violence and Transphobia, and Correlates of Depression Among Male-to-Female Transgender Women With a History of Sex Work
Minority Stress, Resilience, and Mental Health
The Multidimensional Scale of Perceived Social Support
Assessing coping strategies
Coping as a mediator of emotion
Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations
| Citation velocity | historical |
|---|---|
| Highly cited | No |