Comparing plasma levels and ratios of tryptophan, serotonin, kynurenine and quinolinic acid between patients with bipolar disorder and healthy controls
Impact of depressive episode or post-traumatic stress disorder symptoms
Bibliographic Data
| ID | 15524823 |
|---|---|
| Authors | Valerio Dell’Oste (0000-0003-0520-4785), Lionella Palego (0000-0003-3881-0220, University of Pisa), Andrea Bordacchini (University of Pisa), Berenice Rimoldi (University of Pisa), Livia Parrini, Virginia Pedrinelli (0000-0002-3105-893X, Azienda Usl Toscana Centro), Gino Giannaccini (0000-0001-6436-8187, University of Pisa), Laura Betti (0000-0001-6357-8983, University of Pisa), Claudia Carmassi (0000-0002-3662-8073, University of Pisa) |
| Year | 2026 |
| Volume | 16 |
| Pages | 1680907-1680907 |
| Publication date | 2026-01-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1680907 |
| PMID | 41601513 |
| OpenAlex | W7122400093 |
| Language | EN |
| References cited | 146 |
Substantially, BD-patients with low 5-HT and severe burden could be distinguished based on KYN profiles/trajectories when affected by depression or PTSD, entailing different neuroinflammatory/neuroendocrine patterns in mood vs. post-traumatic stress dimensions. This will encourage deeper assessment of BD metabolic/inflammatory biomarkers, allowing for refined patients' stratifications and targeted therapeutic interventions
Bipolar disorder · Depression (economics · Kynurenine · Kynurenine pathway · Major depressive disorder · Mood · Plasma levels · Quinolinic acid · Bipolar Disorder and Treatment · Treatment of Major Depression · Tryptophan and brain disorders
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The role of inflammation in depression
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Posttraumatic Stress Disorder and Chronic Pain Conditions in Men
High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample
Blunted Nocturnal Salivary Melatonin Secretion Profiles in Military-Related Posttraumatic Stress Disorder
Comparing the metabolic pathways of different clinical phases of bipolar disorder through metabolomics studies
Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk
| Citation velocity | historical |
|---|---|
| Highly cited | No |