Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum
A Preliminary Study
Bibliographic Data
| ID | 15524877 |
|---|---|
| Authors | David A Nielsen (0000-0002-2583-0233, Baylor College of Medicine, corresponding author), Wen Huang (0000-0003-3926-4022, Baylor College of Medicine), Sara Hamon (0000-0002-2413-2302, Rockefeller University), Sara C Hamon, Lorena Maili (0000-0001-7695-4319, The University of Texas Health Science Center at Houston), Brian M Witkin (The University of Texas Medical Branch at Galveston), Robert G Fox (The University of Texas Medical Branch at Galveston), Kathryn A Cunningham (0000-0002-4257-1739, The University of Texas Medical Branch at Galveston), F Gerard Moeller (0000-0003-3683-1407, The University of Texas Health Science Center at Houston) |
| Year | 2012 |
| Volume | 3 |
| Pages | 60-60 |
| Publication date | 2012-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2012.00060 |
| PMID | 22712019 |
| PMCID | PMC3374938 |
| OpenAlex | W1966615220 |
| Language | EN |
| References cited | 4 |
Forced abstinence from cocaine self-administration was associated with differences in DNA methylation at specific CpG sites in the promoter region of the Sox10 gene in corpus callosum. These changes may be related to reductions in normal age related changes in DNA methylation and could be a factor in white matter alterations seen after withdrawal from repeated cocaine self-administration. Further research is warranted examining the effects of cocaine on DNA methylation in white matter
Abstinence · Biology · Central nervous system · Corpus callosum · CpG site · DNA methylation · Gene · Gene expression · Methylation · Myelin · Myelin basic protein · Psychiatry · White matter · Epigenetics and DNA Methylation · Medicine · Neurogenesis and neuroplasticity mechanisms · Neuroscience · Prenatal Substance Exposure Effects · Endocrinology · Genetics
| Citation velocity | historical |
|---|---|
| Highly cited | No |