F Gerard Moeller
Biographic Data
| ID | 5854155 |
|---|---|
| NAME | F Gerard Moeller |
| GIVEN NAMES | F Gerard |
| FAMILY NAME | Moeller |
| SIGNATURE | MOELLER F G |
| AFFILIATIONS | Virginia Commonwealth University |
| ORCID | 0000-0003-3683-1407 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 2 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1996 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 1 |
Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls
Resting state functional magnetic resonance imaging (fMRI) has been used to study functional connectivity of brain networks in addictions. However, most studies to-date have focused on the default mode network (DMN) with fewer studies assessing the executive control network (ECN) and salience network (SN), despite well-documented cognitive executive behavioral deficits in addictions. The present study assessed the functional and effective connect…
Initial Validation of a Behavioral Phenotyping Model for Substance Use Disorder
Standard nosological systems, such as DSM-5 or ICD-10, are relied upon as the diagnostic basis when developing treatments for individuals with substance use disorder (SUD). Unfortunately, the vast heterogeneity of individuals within a given SUD diagnosis results in a variable treatment response and/or difficulties ascertaining the efficacy signal in clinical trials of drug development. Emerging precision medicine methods focusing on targeted trea…
Sex Specific Sleep Parameters Among People With Substance Use Disorder
Sleep holds promise as an avenue to address SUD within a biopsychosocial model. Future work at the intersection of SUD and sleep should prioritize investigations of their interplay with sex to identify targets for tailored SUD interventions
Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder
Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT 2C receptor (5-HT 2C R) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT 2C R agonist lorcaserin administered with cocaine in participants with cocaine use disorder (CocUD). Secondarily, subjective response to cocaine and choice of cocaine vs. money were examined. Methods: A double-blind, randomized, placebo-controlled trial of 25 i…
Social Information Processing in Substance Use Disorders
Positive social connections are crucial for recovery from Substance Use Disorder (SUD). Of interest is understanding potential social information processing (SIP) mediators of this effect. To explore whether persons with different SUD show idiosyncratic biases toward social signals, we administered an emotional go-nogo task (EGNG) to 31 individuals with Cocaine Use Disorder (CoUD), 31 with Cannabis Use Disorder (CaUD), 79 with Opioid Use Disorder…
The Impact of Parental Incarceration on Psychopathy, Crime, and Prison Violence in Women
There is a growing interest in understanding the consequences of parental incarceration. Unfortunately, research exploring the long-term criminological and personality effects in female offspring is limited, particularly among second-generation female offenders. In a sample of 170 female offenders, we first assessed the correlations between psychopathy facets, prison violence, and types of crime. Next, we tested the association between childhood …
Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants
Relapse during abstinence in cocaine use disorder (CUD) is often hastened by high impulsivity (predisposition toward rapid unplanned reactions to stimuli without regard to negative consequences) and high cue reactivity (e.g., attentional bias towards drug reward stimuli). A deeper understanding of the degree to which individual biological differences predict or promote problematic behaviors may afford opportunities for clinical refinement and opt…
Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders
Background: Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its various dimensions would have the highest predictive utility for CD. The machine learning approach is highly promising for discoveri…
Bradycardia as a Marker of Chronic Cocaine Use
Few studies have examined the effects of chronic cocaine use on the resting surface electrocardiogram (ECG) between exposures to cocaine. Researchers compared 12-lead ECGs from 97 treatment-seeking cocaine-dependent patients, with ECG parameters from 8,513 non-cocaine-using control patients from the Atherosclerosis Risk in Communities study. After matching and adjusting for relevant covariates, cocaine use demonstrated large and statistically rel…
Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects
These findings are consistent with enhanced dopamine function in the striatum in cocaine dependent subjects via blockade of adenosine A(2A) receptors producing increased brain activation in the orbitofrontal cortex and other cortical regions. This suggests that at least some of the changes in brain activation in prefrontal cortical regions in cocaine dependent subjects may be related to altered striatal dopamine function, and that enhancement of …
Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence
Data from this preliminary investigation fail to provide evidential support for conducting a larger study of this dual-agonist medication combination for treatment of cocaine dependence
Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum
Forced abstinence from cocaine self-administration was associated with differences in DNA methylation at specific CpG sites in the promoter region of the Sox10 gene in corpus callosum. These changes may be related to reductions in normal age related changes in DNA methylation and could be a factor in white matter alterations seen after withdrawal from repeated cocaine self-administration. Further research is warranted examining the effects of coc…
The Influence of Baseline Marijuana Use on Treatment of Cocaine Dependence
The potential moderating effect of marijuana on cocaine treatment response should be considered in future trial designs. Applying Bayesian subgroup analysis proved informative in characterizing this patient-treatment interaction effect
Familial Transmission of Continuous Performance Test Behavior
Continuous Performance Tests (CPTs) provide information on attentional processing and impulsive behavior. The results of previous research that used self-report measures have provided evidence for familial transmission (through genetic and/or environmental influences) of impulsive characteristics. The authors of the present study examined whether the impulsive behavioral parameters that are measured by the CPT also share familial relationships. T…
Psychiatric Aspects of Impulsivity
OBJECTIVE: The authors discuss the relationship of impulsivity to psychiatric disorders and present selected hypotheses regarding the reasons for these relationships. METHOD: Previous research has shown significantly higher levels of impulsivity among patients with conduct disorder, personality disorders, substance use disorders, and bipolar disorder, compared to other psychiatric patients or healthy comparison subjects. A literature review of th…
Laboratory and questionnaire measures of aggression among female parolees with violent or nonviolent histories
Female parolees were recruited into a laboratory study to determine the relationship between their previous aggression history, questionnaire measures of aggression, and behavioral measures of aggressive responding using a laboratory methodology: the Point Subtraction Aggression Paradigm (PSAP). Subjects were assigned to a violent or nonviolent group based on their criminal history. Subjects participated in sessions in which they were given three…
Effects of menstrual cycle phase on aggression measured in the laboratory
This study investigated the effects of menstrual cycle phase on aggression in two groups of women, which differed in the severity of their self-reported perimenstrual symptoms. A low- and a high-symptom group were recruited using the Menstrual Distress Questionnaire (MDQ) to define the groups. Twenty-two subjects (11 low and 11 high symptom) participated across one menstrual cycle: during the premenstrual, menstrual, midfollicular, and ovulatory …
Laboratory measures of aggressive responding in male parolees with violent and nonviolent histories
Males on parole were recruited into a study to determine the external validity of the ©Point Subtraction Aggression Paradigm, a laboratory procedure for measuring human aggressive responding. Subjects were assigned to either a violent or nonviolent group based on their criminal record and the Brown History of Violence Questionnaire. Subjects participated in six 25-min sessions and completed a series of questionnaires. During the laboratory sessio…
Familial Transmission of Continuous Performance Test Behavior
Continuous Performance Tests (CPTs) provide information on attentional processing and impulsive behavior. The results of previous research that used self-report measures have provided evidence for familial transmission (through genetic and/or environmental influences) of impulsive characteristics. The authors of the present study examined whether the impulsive behavioral parameters that are measured by the CPT also share familial relationships. T…
Laboratory measures of aggressive responding in male parolees with violent and nonviolent histories
Males on parole were recruited into a study to determine the external validity of the ©Point Subtraction Aggression Paradigm, a laboratory procedure for measuring human aggressive responding. Subjects were assigned to either a violent or nonviolent group based on their criminal record and the Brown History of Violence Questionnaire. Subjects participated in six 25-min sessions and completed a series of questionnaires. During the laboratory sessio…
Effects of menstrual cycle phase on aggression measured in the laboratory
This study investigated the effects of menstrual cycle phase on aggression in two groups of women, which differed in the severity of their self-reported perimenstrual symptoms. A low- and a high-symptom group were recruited using the Menstrual Distress Questionnaire (MDQ) to define the groups. Twenty-two subjects (11 low and 11 high symptom) participated across one menstrual cycle: during the premenstrual, menstrual, midfollicular, and ovulatory …
Laboratory and questionnaire measures of aggression among female parolees with violent or nonviolent histories
Female parolees were recruited into a laboratory study to determine the relationship between their previous aggression history, questionnaire measures of aggression, and behavioral measures of aggressive responding using a laboratory methodology: the Point Subtraction Aggression Paradigm (PSAP). Subjects were assigned to a violent or nonviolent group based on their criminal history. Subjects participated in sessions in which they were given three…
Psychiatric Aspects of Impulsivity
OBJECTIVE: The authors discuss the relationship of impulsivity to psychiatric disorders and present selected hypotheses regarding the reasons for these relationships. METHOD: Previous research has shown significantly higher levels of impulsivity among patients with conduct disorder, personality disorders, substance use disorders, and bipolar disorder, compared to other psychiatric patients or healthy comparison subjects. A literature review of th…
Familial Transmission of Continuous Performance Test Behavior
Continuous Performance Tests (CPTs) provide information on attentional processing and impulsive behavior. The results of previous research that used self-report measures have provided evidence for familial transmission (through genetic and/or environmental influences) of impulsive characteristics. The authors of the present study examined whether the impulsive behavioral parameters that are measured by the CPT also share familial relationships. T…
Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects
These findings are consistent with enhanced dopamine function in the striatum in cocaine dependent subjects via blockade of adenosine A(2A) receptors producing increased brain activation in the orbitofrontal cortex and other cortical regions. This suggests that at least some of the changes in brain activation in prefrontal cortical regions in cocaine dependent subjects may be related to altered striatal dopamine function, and that enhancement of …
Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence
Data from this preliminary investigation fail to provide evidential support for conducting a larger study of this dual-agonist medication combination for treatment of cocaine dependence
Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum
Forced abstinence from cocaine self-administration was associated with differences in DNA methylation at specific CpG sites in the promoter region of the Sox10 gene in corpus callosum. These changes may be related to reductions in normal age related changes in DNA methylation and could be a factor in white matter alterations seen after withdrawal from repeated cocaine self-administration. Further research is warranted examining the effects of coc…
The Influence of Baseline Marijuana Use on Treatment of Cocaine Dependence
The potential moderating effect of marijuana on cocaine treatment response should be considered in future trial designs. Applying Bayesian subgroup analysis proved informative in characterizing this patient-treatment interaction effect
Bradycardia as a Marker of Chronic Cocaine Use
Few studies have examined the effects of chronic cocaine use on the resting surface electrocardiogram (ECG) between exposures to cocaine. Researchers compared 12-lead ECGs from 97 treatment-seeking cocaine-dependent patients, with ECG parameters from 8,513 non-cocaine-using control patients from the Atherosclerosis Risk in Communities study. After matching and adjusting for relevant covariates, cocaine use demonstrated large and statistically rel…
Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders
Background: Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its various dimensions would have the highest predictive utility for CD. The machine learning approach is highly promising for discoveri…
The Impact of Parental Incarceration on Psychopathy, Crime, and Prison Violence in Women
There is a growing interest in understanding the consequences of parental incarceration. Unfortunately, research exploring the long-term criminological and personality effects in female offspring is limited, particularly among second-generation female offenders. In a sample of 170 female offenders, we first assessed the correlations between psychopathy facets, prison violence, and types of crime. Next, we tested the association between childhood …
Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants
Relapse during abstinence in cocaine use disorder (CUD) is often hastened by high impulsivity (predisposition toward rapid unplanned reactions to stimuli without regard to negative consequences) and high cue reactivity (e.g., attentional bias towards drug reward stimuli). A deeper understanding of the degree to which individual biological differences predict or promote problematic behaviors may afford opportunities for clinical refinement and opt…
Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder
Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT 2C receptor (5-HT 2C R) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT 2C R agonist lorcaserin administered with cocaine in participants with cocaine use disorder (CocUD). Secondarily, subjective response to cocaine and choice of cocaine vs. money were examined. Methods: A double-blind, randomized, placebo-controlled trial of 25 i…
Social Information Processing in Substance Use Disorders
Positive social connections are crucial for recovery from Substance Use Disorder (SUD). Of interest is understanding potential social information processing (SIP) mediators of this effect. To explore whether persons with different SUD show idiosyncratic biases toward social signals, we administered an emotional go-nogo task (EGNG) to 31 individuals with Cocaine Use Disorder (CoUD), 31 with Cannabis Use Disorder (CaUD), 79 with Opioid Use Disorder…
Sex Specific Sleep Parameters Among People With Substance Use Disorder
Sleep holds promise as an avenue to address SUD within a biopsychosocial model. Future work at the intersection of SUD and sleep should prioritize investigations of their interplay with sex to identify targets for tailored SUD interventions
Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls
Resting state functional magnetic resonance imaging (fMRI) has been used to study functional connectivity of brain networks in addictions. However, most studies to-date have focused on the default mode network (DMN) with fewer studies assessing the executive control network (ECN) and salience network (SN), despite well-documented cognitive executive behavioral deficits in addictions. The present study assessed the functional and effective connect…
Initial Validation of a Behavioral Phenotyping Model for Substance Use Disorder
Standard nosological systems, such as DSM-5 or ICD-10, are relied upon as the diagnostic basis when developing treatments for individuals with substance use disorder (SUD). Unfortunately, the vast heterogeneity of individuals within a given SUD diagnosis results in a variable treatment response and/or difficulties ascertaining the efficacy signal in clinical trials of drug development. Emerging precision medicine methods focusing on targeted trea…
Psychology (16 works) · Medicine (12 works) · Psychiatry (12 works) · Clinical Psychology (10 works) · Cognition (7 works) · Clinical Psychology (5 works) · Developmental psychology (5 works) · Impulsivity (5 works) · Internal Medicine (5 works) · Anesthesia (4 works)