Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects

Bibliographic Data

ID15530295
AuthorsF Gerard Moeller (0000-0003-3683-1407, The University of Texas Health Science Center at Houston, corresponding author), Joel L Steinberg (0000-0002-0297-0751, The University of Texas Health Science Center at Houston), Scott D Lane (0000-0002-3447-6539, The University of Texas Health Science Center at Houston), Kimberly L Kjome (The University of Texas Health Science Center at Houston), Liangsuo Ma (0000-0002-8856-098X, The University of Texas Health Science Center at Houston), Sergi Ferré (0000-0002-1747-1779, National Institutes of Health), Joy M Schmitz (0000-0002-3561-4614, The University of Texas Health Science Center at Houston), Charles E Green (0000-0001-9192-8215, The University of Texas Health Science Center at Houston), Stephen I Bandak (Vital Therapies (United States)), Perry F Renshaw (0000-0002-8888-4503, University of Utah), Larry A Kramer (0000-0002-1450-9479, The University of Texas Health Science Center at Houston), Ponnada A Narayana (0000-0002-5703-4346, The University of Texas Health Science Center at Houston)
Year2012
Volume3
Pages44-44
Publication date2012-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2012.00044
PMID22654774
PMCIDPMC3361057
OpenAlexW2104088325
LanguageEN
References cited4

These findings are consistent with enhanced dopamine function in the striatum in cocaine dependent subjects via blockade of adenosine A(2A) receptors producing increased brain activation in the orbitofrontal cortex and other cortical regions. This suggests that at least some of the changes in brain activation in prefrontal cortical regions in cocaine dependent subjects may be related to altered striatal dopamine function, and that enhancement of dopamine function via adenosine A(2A) receptor blockade could be explored further for amelioration of neurobehavioral deficits associated with chronic cocaine use

Adenosine · Adenosine A2A receptor · Adenosine receptor · Agonist · Anesthesia · Antagonist · Brain stimulation reward · Cognition · Dopamine · Nucleus accumbens · Orbitofrontal cortex · Prefrontal cortex · Receptor · Attention Deficit Hyperactivity Disorder · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology · Schizophrenia research and treatment · Internal Medicine · Pharmacology

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