Altered Cerebral Blood Flow in Alzheimer's Disease With Depression
Bibliographic Data
| ID | 15524939 |
|---|---|
| Authors | Runzhi Li (0000-0003-0117-4195, Beijing Tian Tan Hospital), Yanling Zhang (0000-0003-3496-1822, Capital Medical University), Zhizheng Zhuo (0000-0002-6635-8705, Beijing Tian Tan Hospital), Yanli Wang (0000-0001-8126-1904, Capital Medical University), Ziyan Jia (Beijing Tian Tan Hospital), Mengfan Sun (Beijing Tian Tan Hospital), Yuan Zhang (0000-0002-0902-9585, Beijing Tian Tan Hospital), Wenyi Li (0000-0001-6346-9306, Beijing Tian Tan Hospital), Yunyun Duan (0000-0002-8753-0260, Capital Medical University), Zeshan Yao, Haoyi Weng (0009-0001-2652-3040), Juan Wei (0000-0001-8665-2621), Yaou Liu (0000-0002-9930-0331, Capital Medical University, corresponding author), Jun Xu (0000-0002-0557-2046, Beijing Tian Tan Hospital, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 687739-687739 |
| Publication date | 2021-07-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.687739 |
| PMID | 34305683 |
| OpenAlex | W3181989651 |
| Language | EN |
| References cited | 5 |
Background: Depression is common in Alzheimer's disease (AD) with an unclear neural mechanism. This study aimed to investigate the underlying cerebral perfusion associated with depression in AD and evaluate its clinical significance. Method: Twenty-one AD patients and 21 healthy controls (HCs) were enrolled in this study. The depressive symptom was defined according to the Hamilton Depression Rating Scale (HAMD). Nine patients were diagnosed as AD with depression symptoms (HAMD >7). Three-dimensional pseudocontinuous arterial spin labeling MR imaging was conducted to measure regional cerebral blood flow (CBF). Neuropsychological tests covered cognition and depressive scores. Between-group comparisons on clinical variables and regional CBFs, relationship between regional CBF and depressive score, and identification of AD patients with depression were performed using covariance analysis, linear regression, and receiver operating characteristic (ROC) analysis, respectively. Results: Compared with HCs, AD patients without depression exhibited lower gray matter CBF ( p = 0.016); compared with AD patients without depression, AD patients with depression had higher CBF in the right supplementary motor area (39.23 vs. 47.91 ml/100 g/min, p = 0.017) and right supramarginal gyrus (35.54 vs. 43.85 ml/100 g/min, p = 0.034). CBF in the right supplementary motor area was correlated with depressive score (β = 0.46, p = 0.025). The combination of CBF in the right supplementary motor area and supramarginal gyrus and age could identify AD patients with depression from those without depression with a specificity of 100%, sensitivity of 66.67%, accuracy of 85.71%, and area under the curve of 0.87. Conclusions: Our findings suggested that hyperperfusion of the right supplementary motor area and right supramarginal gyrus were associated with depression syndrome in AD, which could provide a potential neuroimaging marker to evaluate the depression state in AD
Cardiology · Cerebral blood flow · Cognition · Depression (economics · Hamd · Neuropsychology · Psychiatry · Advanced Neuroimaging Techniques and Applications · Dementia and Cognitive Impairment Research · Functional Brain Connectivity Studies · Medicine · Psychology · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |