The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia
Bibliographic Data
| ID | 15525136 |
|---|---|
| Authors | Xingjie Peng (National Clinical Research), Gangrui Hei (0000-0003-2978-9423, Hunan Institute of Mental Health), Ye Yang (0000-0003-2827-3572, Central South University), Chenchen Liu (0000-0001-9522-8312, Central South University), Jingmei Xiao (Second Xiangya Hospital of Central South University), Yujun Long (0000-0001-9458-8068, Central South University), Jing Huang (0000-0002-6205-0025, Central South University), Jingping Zhao (0000-0001-5940-653X, Second Xiangya Hospital of Central South University), Renrong Wu (0000-0003-1758-4738, Hunan Institute of Mental Health, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 638773-638773 |
| Publication date | 2021-02-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.638773 |
| PMID | 33716832 |
| OpenAlex | W3135538626 |
| Language | EN |
| Citations received | 1 |
| References cited | 3 |
Background: Schizophrenia is a severe mental disease which characterized by positive symptom, negative symptom, general pathology syndrome and cognitive deficits. In recent years, many studies have investigated the relationship between cognitive deficits and clinical characteristics in schizophrenia, but relatively few studies have been performed on first-episode drug-naïve patients. Methods: Eighty seven first-episode drug-naïve schizophrenia patients were assessed for positive symptom, negative symptom, general pathology symptom and cognitive deficits from the Positive and Negative Symptom Scale and MATRICS Consensus Cognitive Battery. Psychotics depression were assessed using the Calgary depressing scale for schizophrenia. The relationship between clinical characteristics and cognitive deficits were assessed using correlation analysis and linear regression analysis. Results: The prevalence of cognitive deficits among the patients in our study was 85.1% (74/87) which was much higher than that in the general population. According to correlation analysis, negative symptom was negatively correlated with speed of processing and social cognition, and general pathology showed a negative correlation with attention/vigilance. In addition, a positive correlation was found between age and speed of processing. No correlation was found between cognitive deficits and positive symptom. Conclusions: This study confirmed that negative symptom is negatively related with some domains of cognitive function in first-episode drug naïve schizophrenia patients. Trail Registration: NCT03451734. Registered March 2, 2018 (retrospectively registered)
Association (psychology · Cognition · Drug · Drug-naïve · Psychiatry · Psychotherapist · Schizophrenia (object-oriented programming · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Clinical Psychology · Medicine · Mental Health Research Topics · Psychology · Schizophrenia research and treatment
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,33 |
| Citation span | 2023 - 2023 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |