Trapped in a Glass Bell Jar

Neural Correlates of Depersonalization and Derealization in Subjects at Clinical High-Risk of Psychosis and Depersonalization–Derealization Disorder

Bibliographic Data

ID15525308
AuthorsJessica R Büetiger (0000-0001-7924-1314, University of Bern), Daniela Hubl (University Hospital of Bern), Stephan Kupferschmid (0000-0002-9721-3322, Integrierte Psychiatrie Winterthur), Frauke Schultze‐Lutter (0000-0003-1956-9574, Heinrich Heine University Düsseldorf), Frauke Schultze-Lutter, Benno G Schimmelmann (0000-0002-8980-1466, University Medical Center Hamburg-Eppendorf), Andrea Federspiel (0000-0003-3211-2675, University Hospital of Bern), Martinus Hauf (University of Bern), Sebastian Walther (0000-0003-4026-3561, University Hospital of Bern), Michael Kaess (0000-0003-0031-7764, University of Bern), Chantal Michel (0000-0003-1165-6681, University of Bern), Jochen Kindler (0000-0002-9034-2770, University of Bern, corresponding author)
Year2020
Volume11
Pages535652-535652
Publication date2020-09-11
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.535652
PMID33024435
OpenAlexW3086785821
LanguageEN
References cited79

This study shows that DP/DR symptoms are frequently found in CHR subjects. Investigating two separate DP/DR populations with an identical neuroimaging technique, our study also indicates that there may be divergent pathophysiological mechanisms-decreased neuronal activity in the orbitofrontal cortex, but increased activity within the caudate nucleus-leading to a final common pathway with similar psychopathological symptoms. This suggests that both top-down (orbitofrontal cortex) and bottom-up (caudate nucleus) mechanisms could contribute to the emergence of DP/DR

Depersonalization · Derealization · Distress · Emotional exhaustion · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Clinical Psychology · Medicine · Mental Health and Psychiatry · Psychology · Psychosomatic Disorders and Their Treatments · Schizophrenia research and treatment · Internal Medicine

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