The Interaction Between Genetic Variant ZNF804A rs1344706 and Alcohol Withdrawal on Impulsivity
Evidence for the Diathesis-Stress Model
Bibliographic Data
| ID | 15525604 |
|---|---|
| Authors | Xie Zhang (0000-0002-3113-9633, Ningbo Medical Center Lihuili Hospital), Huankun Sun (Wenzhou Medical University), Fan Wang (0000-0002-9869-9504, Peking University), Michelle Niculescu (Chatham University), Guanghui Shen (0000-0002-4253-695X, Wenzhou Medical University), Siyao Zhou (0009-0005-9352-443X, Wenzhou Medical University), Fan Yang (0000-0003-2978-7102, Wenzhou Medical University), Yu‐hsin Chen (0000-0002-7829-4008, Wenzhou-Kean University), Li Chen (0000-0002-8432-3338, Wenzhou Medical University, corresponding author), Wei Wang (0000-0001-5806-2368, Wenzhou Medical University, corresponding author), Yanlong Liu (0000-0002-5254-3897, Wenzhou Medical University, corresponding author) |
| Year | 2022 |
| Volume | 12 |
| Pages | 761237-761237 |
| Publication date | 2022-01-03 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.761237 |
| PMID | 35046850 |
| OpenAlex | W4205269747 |
| Language | EN |
| Citations received | 1 |
| References cited | 6 |
Objective: Alcohol use disorder (AUD) is the most common substance use disorder, which may relate to increased impulsivity. A more detailed understanding of the potential moderating factor on association between AUD and impulsivity is likely to have far-reaching effects. This study aims to examine whether the interaction between a genetic variant ZNF804A rs1344706 and alcohol use is related to impulsivity in Chinese Han adult males diagnosed with AUD. Methods: A total of 455 Chinese Han adult males diagnosed with AUD were included in this study. Impulsivity was assessed using Barratt Impulsiveness Scale. Alcohol dependence was measured by Michigan Alcoholism Screening Test. Genomic DNA was extracted from peripheral blood of participants and genotyped. Results: Hierarchical multiple regression yielded a significant interaction between ZNF804A rs1344706 and alcohol use (β = 0.20, p = 0.0237). Then, A region of significance (RoS) test was performed to interpret the interaction effect. Re-parameterized regression models revealed that the interaction between ZNF804A rs1344706 and alcohol problem severity fit to the weak diathesis-stress model ( R 2 = 0.15, p Conclusions: This study, which analyzed a specific gene-environment interaction, demonstrated that carriers of the T allele of ZNF804A rs1344706 may be more susceptible to alcohol problem severity, correlated with higher levels of impulsivity during withdrawal
Alcohol · Alcohol dependence · Alcohol use disorder · Barratt Impulsiveness Scale · Biology · Diathesis · Impulsivity · Psychiatry · Alcohol Consumption and Health Effects · Clinical Psychology · Medicine · Neurotransmitter Receptor Influence on Behavior · Psychology · Substance Abuse Treatment and Outcomes
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |