Adverse Childhood Experiences and Neurocognition in Schizophrenia Spectrum Disorders
Age at First Exposure and Multiplicity Matter
Bibliographic Data
| ID | 15525983 |
|---|---|
| Authors | Justyna Kasznia, Aleksandra Pytel (0000-0001-9667-0700, Wroclaw Medical University), Bartłomiej Stańczykiewicz (0000-0001-9221-3502, Wroclaw Medical University), Jerzy Samochowiec (0000-0003-1438-583X, Pomeranian Medical University), Joanna Preś (0000-0002-1148-0957, Pomeranian Medical University), Karolina Rachubińska (0000-0002-0525-2974, University of Szczecin), Błażej Misiak (0000-0002-5392-6398, Wroclaw Medical University, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 684099-684099 |
| Publication date | 2021-07-05 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.684099 |
| PMID | 34305680 |
| OpenAlex | W3182953532 |
| Language | EN |
| Citations received | 2 |
| References cited | 43 |
Adverse childhood experiences (ACEs) might be related to cognitive impairments observed in schizophrenia spectrum disorders (SSD). However, it remains unknown what aspects of ACEs are associated with cognitive impairments in SSD. Therefore, we aimed to investigate the association between various characteristics of ACEs (age at first exposure, severity, and multiplicity) and cognition in SSD and healthy controls (HCs). We enrolled 127 individuals with SSD and 56 HCs. Cognitive performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The Childhood Experience of Care and Abuse Questionnaire was administered to record a history of ACEs. The following characteristics of ACEs were analyzed: multiplicity, severity, and age at first exposure. Individuals with SSD had significantly lower scores on all RBANS domains. Multiplicity and severity of ACEs were significantly higher in patients with SSD compared to HCs. In both groups, greater multiplicity of ACEs was associated with lower scores of global cognition and delayed memory. Additionally, in subjects with SSD, greater multiplicity and younger age at first exposure were associated with lower scores of attention. The present findings indicate that greater multiplicity and younger age at first exposure are the most important aspects of ACEs contributing to cognitive impairments observed in SSD. Moreover, ACEs might exert differential impact on cognition in SSD and HCs
Cognition · Neurocognitive · Neuropsychology · Psychiatry · Repeatable Battery for the Assessment of Neuropsychological Status · Child Abuse and Trauma · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Medicine · Psychology · Schizophrenia research and treatment
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
Childhood Adversities Increase the Risk of Psychosis
Stress signalling pathways that impair prefrontal cortex structure and function
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder
| Citations per year | 1 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |