A DRD2/ANNK1–Comt Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese
Bibliographic Data
| ID | 15526644 |
|---|---|
| Authors | Kunlin Zhang (0000-0003-0284-1666, University of Chinese Academy of Sciences), Li Wang (0000-0002-3460-2080, Institute of Psychology, Chinese Academy of Sciences, corresponding author), Chengqi Cao (0000-0002-0320-7395, Shenzhen University), Gen Li (0000-0003-4910-0523, University of Chinese Academy of Sciences), Ruojiao Fang (University of Chinese Academy of Sciences), Ping Liu (0000-0002-8713-1999, Deyang Stomatological Hospital), Shu Luo (0000-0003-2911-4434, Deyang Stomatological Hospital), Xiangyang Zhang (0000-0003-3326-382X, Institute of Psychology, Chinese Academy of Sciences), Israel Liberzon (0000-0002-4990-556X, University of Michigan) |
| Year | 2018 |
| Volume | 9 |
| Pages | 170-170 |
| Publication date | 2018-04-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00170 |
| PMID | 29760667 |
| OpenAlex | W2800695924 |
| Language | EN |
| Citations received | 2 |
| References cited | 8 |
Objective: Post-traumatic stress disorder (PTSD) is a trauma- and stress-related psychiatric syndrome that occurs after exposure to extraordinary stressors. The neurotransmitter dopamine (DA) plays important roles in neurobiological processes like reward and stress, and a link between PTSD and the dopaminergic system has been reported. Thus, the investigation of an association between PTSD and gene-gene interaction (epistasis) within dopaminergic genes could uncover the genetic basis of dopamine-related PTSD symptomatology and contribute to precision medicine. Methods: We genotyped seven single nucleotide polymorphisms (SNPs) of three dopaminergic genes DRD2/ANNK1 (rs1800497 and rs1801028), COMT (rs6269, rs4633, rs4818 and rs4680) and DBH (rs1611115), in a Chinese predominantly adult cohort that had been exposed to an earthquake (156 PTSD cases and 978 controls). Results: Statistical genetics analysis identified a DRD2/ANNK1 - COMT interaction (rs1800497 × rs6269), which is associated with PTSD diagnosis ( P interaction = 0.0008055 and P corrected = 0.0169155). Single-variant and haplotype-based subset analyses showed that rs1800497 modulates the association directions of both the rs6269 G allele and the rs6269-rs4633-rs4818-rs4680 haplotype G-C-G-G. The interaction (rs1800497 × rs6269) was replicated in a Chinese young female cohort (32 cases and 581 controls, P interaction = 0.01329). Conclusions: Rs1800497 is related to the DA receptor D2 density and rs6269-rs4633-rs4818-rs4680 haplotypes affect the catechol O-methyltransferase level and enzyme activity. Thus, the interaction was inferred to be at protein-protein and DA activity level. The genotype combinations of the two SNPs indicate a potential origin of DA homeostasis abnormalities in PTSD development
Major depressive disorder · Mood · Psychiatry · Traumatic stress · Clinical Psychology · Medicine · Neuroblastoma Research and Treatments · Psychology · Schizophrenia research and treatment · Traumatic Brain Injury Research
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| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2021 (1) |
| Highly cited | No |