Self-Awareness of Psychopathology and Brain Volume in Patients With First Episode Psychosis
Bibliographic Data
| ID | 15526711 |
|---|---|
| Authors | Jeong-Youn Kim (0000-0003-4144-4065, Inje University), Hyeonjin Jeon (0000-0002-8206-2349, Inje University), Aeran Kwon (0000-0001-5874-3657, Inje University), Min Jin Jin (0000-0001-5494-5702, Chung-Ang University), Seung-hwan Lee (0000-0003-0305-3709, Inje University, corresponding author), Young‐Chul Chung (0000-0001-9491-1822, Jeonbuk National University, corresponding author), Young-Chul Chung |
| Year | 2019 |
| Volume | 10 |
| Pages | 839-839 |
| Publication date | 2019-11-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00839 |
| PMID | 31803084 |
| OpenAlex | W2984409048 |
| Language | EN |
| Citations received | 1 |
| References cited | 124 |
Memory impairment, excessive rumination, and increased interpersonal sensitivity are major characteristics of high psychosis risk or first episode psychosis (FEP). Herein, we investigated the relationship between brain volume and self-awareness of psychopathology in patients with FEP. All participants (FEP: 34 and HCs: 34) completed clinical assessments and the following self-reported psychopathology evaluations: prospective and retrospective memory questionnaire (PRMQ), ruminative response scale (RRS), and interpersonal sensitivity measure (IPSM). Structural magnetic resonance imaging was then conducted. The PRMQ, RRS, and IPSM scores were significantly higher in the FEP group than in the healthy controls (HCs). The volumes of the amygdala, hippocampus, and superior temporal gyrus (STG) were significantly lower in the FEP group than in the HCs. There was a significant group-dependent moderation effect between self-awareness of psychopathology (PRMQ, RRS, and IPSM scores) and right STG (rSTG) volume. In the FEP group, self-awareness of psychopathology was positively associated with rSTG volume, while in the HCs, this correlation was negative. Our results indicate that self-awareness of psychopathology impacts rSTG volume in the opposite direction between patients with FEP and HCs. In patients with FEP, awareness of impairment may induce increases in rSTG brain volume. However, HCs showed decreased rSTG volume when they were aware of impairment
Amygdala · Hippocampus · Psychiatry · Psychopathology · Psychosis · Schizophrenia (object-oriented programming · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Psychology · Schizophrenia research and treatment · Internal Medicine
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| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |