How Impulsiveness Influences Obesity
The Mediating Effect of Resting-State Brain Activity in the dlPFC
Bibliographic Data
| ID | 15526763 |
|---|---|
| Authors | Xiao-dong Han, Xiaodong Han (0000-0003-4512-3699, Shanghai Jiao Tong University), Hongwei Zhang (0000-0002-9137-2349, Shanghai Jiao Tong University), Hong-Wei Zhang (0000-0001-7508-5553), Ting Xu (0000-0001-5392-4731, Shanghai Jiao Tong University, corresponding author), Lin Liu (0000-0002-7202-3418, Shanghai Jiao Tong University), Hui-Ting Cai (0000-0002-8429-1444, Shanghai Jiao Tong University), Zi-Qi Liu, Ziqi Liu (0000-0001-9587-9705, Shanghai Jiao Tong University), Qing Li (0000-0002-2449-1655, Shanghai Jiao Tong University), Hui Zheng (0000-0002-7217-5032, Shanghai Jiao Tong University, corresponding author), Tao Xu (0000-0002-0501-6445, Tongji University), Ti-Fei Yuan (0000-0003-0510-715X, Tongji University, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 873953-873953 |
| Publication date | 2022-05-10 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.873953 |
| PMID | 35619620 |
| OpenAlex | W4229449787 |
| Language | EN |
| Citations received | 1 |
| References cited | 51 |
Impulsiveness is a stable personal characteristic that contributes to obesity and may interact with it. Specifically, obesity is caused by unrestrained impulse eating that is not consciously controlled and leads to a hormonal imbalance that also can impair impulse control. However, the mechanism of this relationship is unclear. In our study, 35 obese individuals (body mass index, BMI > 28) were recruited and matched with 31 healthy controls (BMI < 24) in age and education level. All the participants underwent a resting-state fMRI and completed the Barratt Impulsiveness Scale-11. The results showed that patients with obesity had a significantly lower fractional amplitude of low-frequency fluctuations (fALFF) in the bilateral dorsolateral prefrontal cortex (dlPFC) and higher fALFF in the left fusiform cortex. In addition, non-planning impulsiveness was positively correlated with BMI. Importantly, we found that the right dlPFC completely mediated the relationship between non-planning impulsiveness and BMI. Our findings suggest that impulsivity is statistically more likely to precede obesity than to precede impulsivity and contributes to obesity by downregulating spontaneous activity in the dlPFC. This suggests that the dlPFC, which is associated with executive control, may be able a potential target for treating obesity
Barratt Impulsiveness Scale · Body mass index · Brain activity and meditation · Cognition · Developmental psychology · Dorsolateral prefrontal cortex · Electroencephalography · Impulsivity · Obesity · Prefrontal cortex · Resting state fMRI · Functional Brain Connectivity Studies · Heart Rate Variability and Autonomic Control · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Internal Medicine
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| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |