Imaging oxidative stress in brains of chronic methamphetamine users

A combined 1H-magnetic resonance spectroscopy and peripheral blood biomarker study

Bibliographic Data

ID15526796
AuthorsSarah E Watling (Centre for Addiction and Mental Health), Samantha Jagasar (Centre for Addiction and Mental Health), Tina McCluskey (0000-0002-6795-4808, Centre for Addiction and Mental Health), Jerry J Warsh (University of Toronto), Jerry Warsh, Shawn G Rhind (0000-0003-2300-0620, Defence Research and Development Canada), Peter Truong (Centre for Addiction and Mental Health), Sofia Chavez (0000-0002-6532-911X, Centre for Addiction and Mental Health), Sylvain Houle (0000-0002-4231-6316, Centre for Addiction and Mental Health), Junchao Tong (0000-0001-9299-0045, Centre for Addiction and Mental Health), Stephen J Kish (0000-0003-0237-1756, University of Toronto), Isabelle Boileau (0000-0002-9901-1484, University of Toronto, corresponding author)
Year2023
Volume13
Pages1070456-1070456
Publication date2023-01-10
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.1070456
PMID36704729
OpenAlexW4317547578
LanguageEN
Citations received1
References cited46

Normal brain GSH in living brain of chronic MA users is consistent with our previous postmortem brain finding and suggests that any oxidative stress caused by MA, at the doses used by our participants, might not be sufficient to cause either a compensatory increase in, or substantial overutilization of, this antioxidant. Additionally, more research is required to understand how oxidative stress and inflammatory processes are related and potentially dysregulated in MA use

Biomarker · Magnetic resonance imaging · Nuclear magnetic resonance · Oxidative stress · Peripheral · Peripheral blood · Physics · Radiology · Advanced MRI Techniques and Applications · Chemistry · Medicine · Metabolomics and Mass Spectrometry Studies · Neuroscience and Neuropharmacology Research · Biochemistry · Internal Medicine

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