Baseline monocyte count predicts symptom improvement during intravenous ketamine therapy in treatment-resistant depression

A single-arm open-label observational study

Bibliographic Data

ID15527006
AuthorsBruno Pedraz-Petrozzi (0000-0002-4119-971X, Central Institute of Mental Health, corresponding author), Moritz Spangemacher (0009-0007-1268-4808, University Hospital Heidelberg, corresponding author), Anton Deicher (Central Institute of Mental Health), Lena Drews (Central Institute of Mental Health), Julie Defert (University Hospital Heidelberg), Ana Yaiza Silva-Colmenero (Heidelberg University), Paul Wein (Central Institute of Mental Health), Elena Riedinger (University Hospital Heidelberg), Gerhard Gründer (0000-0001-7868-3903, Central Institute of Mental Health), Maria Gilles (0000-0002-9604-4459, Heidelberg University), Alexander Sartorius (0000-0002-1243-3693, University Hospital Heidelberg), Jonathan Reinwald (0000-0001-9508-3942, University Medical Center of the Johannes Gutenberg University Mainz), Jonathan R Reinwald
Year2024
Volume15
Pages1415505-1415505
Publication date2024-06-24
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2024.1415505
PMID39045550
OpenAlexW4399983491
LanguageEN
References cited59

Our prospective single-arm open-label observational study demonstrated that baseline AMC reliably predicted symptom improvement during intravenous ketamine treatment in TRD patients. AMC could therefore serve as a simple and easily accessible marker for symptom improvement during ketamine therapy in daily clinical practice. Future studies with larger sample sizes and a more detailed longitudinal assessment of AMC subtypes are needed to better understand the specific relationship between monocytes and the neuromodulatory effects of ketamine

Anesthesia · Antidepressant · Context (archaeology · Depression (economics · Ketamine · Medicine · Stress Responses and Cortisol · Treatment of Major Depression · Tryptophan and brain disorders · Internal Medicine

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