Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe Covid-19 Episode? A Prospective Study

Bibliographic Data

ID15527760
AuthorsHugo Bottemanne (0000-0003-2958-0849, Institut du Cerveau, corresponding author), Clément Gouraud (0000-0002-0433-023X, Hôtel-Dieu de Paris, corresponding author), Jean‐Sébastien Hulot (0000-0001-5463-6117, Centre d'Investigation Clinique Hôpital Européen Georges Pompidou), Anne Blanchard (0000-0002-0815-0586, Assistance Publique – Hôpitaux de Paris), Brigitte Ranque (0000-0001-8549-2275, Assistance Publique – Hôpitaux de Paris), Khadija Lahlou‐Laforêt (Hôpital Européen Georges-Pompidou), Frédéric Limosin (0000-0002-0976-1514, Hôpital Corentin-Celton), Sven Günther (0000-0002-3662-1883, Université Paris Cité), David Lebeaux (0000-0002-7164-831X, Hôpital Européen), Cédric Lemogne (0000-0002-3487-4721, Institut de Psychiatrie et Neurosciences de Paris)
Year2021
Volume12
Pages757685-757685
Publication date2021-11-10
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.757685
PMID34858230
OpenAlexW3213384235
LanguageEN
Citations received3
References cited7

Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presence of fatigue, dyspnea, and pain complaints at 3-month follow-up. Methods: We conducted a prospective study in patients previously hospitalized for COVID-19 followed up for 3 months. The Hospital Anxiety and Depression Scale (HAD-S) was administered by physicians at 1-month follow-up, and the presence of fatigue, dyspnea, and pain complaints was assessed at both 1 month and 3 months. Multivariable logistic regressions explored the association between anxiety and depression subscores and the persistence of each of the physical symptom at 3 months. Results: A total of 84 patients were included in this study (Median age: 60 years, interquartile range: 50.5-67.5 years, 23 women). We did not find any significant interaction between anxiety and the presence of fatigue, dyspnea, or pain complaints at 1 month in predicting the persistence of these symptoms at 3 months (all p ≥ 0.36). In contrast, depression significantly interacted with the presence of pain at 1 month in predicting the persistence of pain at 3 months (OR: 1.60, 95% CI: 1.02-2.51, p = 0.039), with a similar trend for dyspnea (OR: 1.51, 95% CI: 0.99-2.28, p = 0.052). Discussion and Conclusion: Contrary to anxiety, depression after an acute COVID-19 episode may be associated with and increased risk of some persistent physical symptoms, including pain and dyspnea

Anxiety · Coronavirus disease 2019 (COVID-19 · Depression (economics · Disease · Hospital Anxiety and Depression Scale · Interquartile range · Logistic regression · Persistence (discontinuity · Physical therapy · Prospective cohort study · Psychiatry · COVID-19 and Mental Health · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19 · Medicine · Internal Medicine

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