Association Between Psychological Distress, Cognitive Complaints, and Neuropsychological Status After a Severe Covid-19 Episode

A Cross-Sectional Study

Bibliographic Data

ID15528104
AuthorsClément Gouraud (0000-0002-0433-023X, Assistance Publique – Hôpitaux de Paris, corresponding author), Hugo Bottemanne (0000-0003-2958-0849, Assistance Publique – Hôpitaux de Paris), Khadija Lahlou-Laforêt, Khadija Lahlou‐Laforêt (Hôpital Européen Georges-Pompidou), Anne Blanchard (0000-0002-0815-0586, Hôpital Européen), Sven Günther (0000-0002-3662-1883, Inserm), Salma El Batti (0000-0002-7156-6891, Hôpital Européen), Édouard Auclin (0000-0001-7039-4840, Assistance Publique – Hôpitaux de Paris), Frédéric Limosin (0000-0002-0976-1514, Assistance Publique – Hôpitaux de Paris), Jean‐Sébastien Hulot (0000-0001-5463-6117, Hôpital Européen), Jean-Sébastien Hulot, David Lebeaux (0000-0002-7164-831X, Hôpital Européen), Cédric Lemogne (0000-0002-3487-4721, Inserm)
Year2021
Volume12
Pages725861-725861
Publication date2021-09-03
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.725861
PMID34539470
OpenAlexW3198880336
LanguageEN
Citations received4
References cited25

Background: Cognitive complaints are frequent after COVID-19 but their clinical determinants are poorly understood. This study aimed to explore the associations of objective cognitive performances and psychological distress with cognitive complaints in COVID-19 survivors. Materials and Methods: Patients previously hospitalized for COVID-19 in a university hospital during the first wave of COVID-19 pandemic in France were followed-up at 1 month after their admission. Cognitive complaints were self-reported and standardized instruments were used to assess neuropsychological status (Digit Symbol Substitution Test, Semantic Verbal Fluency Test, Mini Mental Status Examination) and psychological distress (Hospital Anxiety and Depression Scale, HADS). Multivariable analyses were adjusted for age, sex, admission in intensive care unit (ICU) and need for oxygen and C-reactive protein. Results: One hundred patients (34% women, median age: 60 years [interquartile range: 49-72)] completed the neuropsychological assessment at follow-up. In multivariable analyses, cognitive complaints at 1-month were associated with greater HADS score (OR for one interquartile range: OR: 1.96, 95% CI: 1.08-3.57) and older age (OR: 1.05, 95% CI: 1.01-1.09) and, negatively, with admission in ICU (OR: 0.22, 95% CI: 0.05-0.90). In contrast, none of the objective neuropsychological test scores was significantly associated with cognitive complaints. Exploratory analysis showed that cognitive complaints were associated with both anxiety and depressive symptoms. Discussion: These preliminary results suggest that cognitive complaints at 1 month after a hospitalization for COVID-19 are associated with psychological distress, independently of objective neuropsychological status. Anxiety and depression symptoms should be systematically screened in patients presenting with cognitive complaints after a severe COVID-19 episode

Anxiety · Cognition · Cross-sectional study · Hospital Anxiety and Depression Scale · Interquartile range · Neuropsychology · Psychiatry · Verbal fluency test · Clinical Psychology · COVID-19 and Mental Health · Intensive Care Unit Cognitive Disorders · Long-Term Effects of COVID-19 · Medicine · Psychology · Internal Medicine

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