Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity

Bibliographic Data

ID15528010
AuthorsXianxin Qiu (0000-0002-9823-0992, Wuhan Institute of Physics and Mathematics), Xu Han (0000-0003-4414-8341, Renji Hospital), Yao Wang (0000-0002-7024-4233, Renji Hospital), Weina Ding (Renji Hospital), Yawen Sun (0000-0001-6529-8598, Renji Hospital), Yan Zhou (0000-0002-3659-5881, Renji Hospital), Hao Lei (0000-0003-3412-1241, Chinese Academy of Sciences), Fuchun Lin (0000-0002-2282-6474, Wuhan Institute of Physics and Mathematics, corresponding author)
Year2020
Volume11
Pages586114-586114
Publication date2020-12-03
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.586114
PMID33343420
OpenAlexW3109193885
LanguageEN
Citations received4
References cited83

Converging lines of evidence indicates that smoking and internet gaming disorder (IGD) affect spontaneous brain activity, respectively. However, little is known about whether these two factors work together on the human brain. In this study, we investigated the interaction between smoking and IGD on local spontaneous brain activity using amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI (rs-fMRI). Forty-six cigarette smokers, 38 IGD individuals, 34 participants with both IGD and cigarette smoking (IGD-Smoking), and 60 healthy individuals involved in the study. Voxel-wise analysis of covariance of ALFF revealed that there were significant interactions between IGD by smoking in the right medial pre-frontal cortex (MPFC)/ventral striatum, bilateral cerebellar, and visual-related regions as well as the left temporal gyrus. In the right MPFC/ventral striatum and left temporal gyrus, ALFF in smoking group was significantly higher than healthy group while there were no significant ALFF differences between IGD-Smoking group and IGD group. While in the bilateral cerebellar and visual-related regions, ALFF in the smoking group was significantly lower than healthy group while ALFF in IGD-Smoking group did not show significant difference with IGD group. In addition, in the smoking group, ALFF of the right MPFC/ventral striatum was associated positively with anxiety and depression scores while the ALFF value in the smoking group had a trend toward negative correlation with SDS scores in the bilateral cerebellar and visual-related regions. The ALFF value in the smoking group was associated positively with anxiety score in the left temporal gyrus. These findings indicate that smoking and IGD interacted with each other in the human brain. Our results, in terms of spontaneous brain activity, may imply the fact that IGD people are more tended to get smoking. Moreover, it is possible to predict that smokers may be more easily to get internet addiction than healthy people

Anxiety · Audiology · Immunoglobulin D · Psychiatry · Striatum · Ventral striatum · Functional Brain Connectivity Studies · Heart Rate Variability and Autonomic Control · Medicine · Mental Health Research Topics · Neuroscience · Psychology · Internal Medicine

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