Shared Response Inhibition Deficits but Distinct Error Processing Capacities Between Schizophrenia and Obsessive-Compulsive Disorder Patients Revealed by Event-Related Potentials and Oscillations During a Stop Signal Task
Bibliographic Data
| ID | 15528653 |
|---|---|
| Authors | Fengqiong Yu (0000-0002-6480-4740, Anhui Medical University), Xingui Chen (0000-0001-8861-8101, Anhui Mental Health Center), Lei Zhang (0000-0003-4889-6486, Anhui Mental Health Center), Tongjian Bai (0000-0002-2185-0042, Anhui Medical University), Yaxiang Gao (Anhui Mental Health Center), Yi Dong (0009-0003-0144-4041, Anhui Mental Health Center), Yuejia Luo (0000-0002-3877-0081, Shenzhen University), Chunyan Zhu (0000-0002-3434-2581, Anhui Medical University, corresponding author), Kai Wang (0000-0002-3784-1378) |
| Year | 2019 |
| Volume | 10 |
| Pages | 853-853 |
| Publication date | 2019-11-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00853 |
| PMID | 31798483 |
| OpenAlex | W2989818785 |
| Language | EN |
| Citations received | 2 |
| References cited | 45 |
Background: Schizophrenia (SCH) patients are at high risk for obsessive-compulsive syndrome, which can lead to difficulty in differential diagnosis between SCH and obsessive-compulsive disorder (OCD). It would be of great clinical value to identify objective markers for these diseases based on behavioral or neurological manifestations. Deficient response inhibition has been reported in both SCH and OCD; however, it is unclear if common or distinct neural abnormalities underlie this impairment. Methods: To address this question, we compared Stop signal task performance and associated event-related potentials (ERPs) and event-related oscillation (ERO) among 24 SCH patients, 25 OCD patients, and 27 healthy controls (HCs). Results: In successful Stop trials, both SCH and OCD patients showed prolonged Stop signal response time, reduced ERP-P3 component amplitude, and weaker theta-band synchronization compared to HCs, while there were no significant differences between patient groups. In unsuccessful Stop trials, however, SCH patients demonstrated significantly lower P3 amplitudes and weaker theta-band activity than OCD patients. In addition, Stop accuracy rate in SCH patients was negatively correlated with Positive subscale score of the Positive and Negative Syndrome Scale. Conclusions: These results provide evidence that impaired response inhibition in SCH and OCD arises from common underlying neural processing abnormalities. However, the lower P3 amplitude and weaker theta-band activity in SCH patients in unsuccessful Stop trials suggest distinct neural activity patterns related to error processing. These differences in ERPs and ERO may provide clues to unique neurological abnormalities in SCH and provide objective measures for differential diagnosis
Audiology · Cognition · Differential effects · Electroencephalography · Event-related potential · Neural correlates of consciousness · Obsessive compulsive · Psychiatry · Schizophrenia (object-oriented programming · Stop signal · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Obsessive-Compulsive Spectrum Disorders · Psychology · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 0.4 |
| Citation span | 2021 - 2022 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |