Effects of Immune Activation during Early or Late Gestation on N-Methyl-d-Aspartate Receptor Measures in Adult Rat Offspring

MIA may alter glutamatergic signaling in cortical and hippocampal regions via alterations in NMDAR indices; however, this was independent of gestational timing. Male MIA offspring have exaggerated changes in NMDAR compared to females in both the cortex and striatum. The MIA-induced increase in NR2A may decrease brain plasticity and contribute to the exacerbated behavioral changes reported in males and indicate that the brains of male offspring are more susceptible to long-lasting changes in glutamate neurotransmission induced by developmental inflammation

Andrology · Biology · Gestation · Immune system · Offspring · Pregnancy · Receptor · Electrolyte and hormonal disorders · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Genetics · Immunology · Internal Medicine