Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls

Bibliographic Data

ID15529197
AuthorsCarl Delfin (0000-0003-4827-7650, University of Gothenburg, corresponding author), Emily Ruzich (0000-0001-6612-7600, Sahlgrenska University Hospital), Märta Wallinius (0000-0003-0530-9560, University of Gothenburg), Malin Björnsdotter (0000-0002-6096-1212, University of Gothenburg), Peter Andiné (0000-0002-6748-9619, University of Gothenburg)
Year2020
Volume11
Pages577491-577491
Publication date2020-12-11
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.577491
PMID33362599
OpenAlexW3110671026
LanguageEN
Citations received3
References cited132

Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these two components in violent, inpatient MDOs. Here, we examined self-reported trait disinhibition, experimentally assessed response inhibition, and NoGo N2 and P3 amplitude and latency in male, violent MDOs ( N = 27) and healthy controls ( N = 20). MDOs had a higher degree of trait disinhibition, reduced NoGo P3 amplitude, and delayed NoGo P3 latency compared to controls. The reduced NoGo P3 amplitude and delayed NoGo P3 latency in MDOs may stem from deficits during monitoring or evaluation of behavior. NoGo P3 latency was associated with increased trait disinhibition in the whole sample, suggesting that trait disinhibition may be associated with reduced neural efficiency during later stages of outcome monitoring or evaluation. Findings for NoGo N2 amplitude and latency were small and non-robust. With several limitations in mind, this is the first study to demonstrate attenuated NoGo P3 amplitude and delayed NoGo P3 latency in violent, inpatient MDOs compared to healthy controls

Audiology · Cognition · Developmental psychology · Disinhibition · Event-related potential · Latency (audio · Trait · Attention Deficit Hyperactivity Disorder · Clinical Psychology · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Personality Disorders and Psychopathology · Psychology

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